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UnknownCo-targeting SRC overcomes resistance to BRAF inhibitors in colorectal cancer.

Background

BRAFV600E mutations occur in ∼10% of colorectal cancer (CRC) patients, leading to poor prognosis. Although BRAF-targeted therapy is ineffective in CRC, adding EGFR inhibitors (EGFRi) improves efficacy, yet patient survival remains suboptimal. This study explores SRC as ...
S-EPMC12322152 | biostudies-literature
UnknownAdvances in the Treatment of Gastroenteropancreatic Neuroendocrine Carcinomas: Are we Moving Forward?
Poorly differentiated gastroenteropancreatic neuroendocrine carcinomas are aggressive neoplasms of challenging clinical management. A small proportion of patients with early-stage disease may achieve long-term survival, but the majority of patients present with rapidly lethal metastatic disease. Cur...
S-EPMC10335166 | biostudies-literature
UnknownBeyondcell: targeting cancer therapeutic heterogeneity in single-cell RNA-seq data.
We present Beyondcell, a computational methodology for identifying tumour cell subpopulations with distinct drug responses in single-cell RNA-seq data and proposing cancer-specific treatments. Our method calculates an enrichment score in a collection of drug signatures, delineating therapeutic clust...
S-EPMC8675493 | biostudies-literature
UnknownvulcanSpot: a tool to prioritize therapeutic vulnerabilities in cancer.

Motivation

Genetic alterations lead to tumor progression and cell survival but also uncover cancer-specific vulnerabilities on gene dependencies that can be therapeutically exploited.

Results

vulcanSpot is a novel computational approach implemented to expand the therapeutic options in...
S-EPMC6853644 | biostudies-literature
UnknownMicroRNA signature and integrative omics analyses define prognostic clusters and key pathways driving prognosis in patients with neuroendocrine neoplasms.
Neuroendocrine neoplasms (NENs) are mutationally quiet (low number of mutations/Mb), and epigenetic mechanisms drive their development and progression. We aimed at comprehensively characterising the microRNA (miRNA) profile of NENs, and exploring downstream targets and their epigenetic modulation. I...
S-EPMC10061291 | biostudies-literature
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