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TranscriptomicsA Chondrogenic Molecule that Repairs Cartilage by Transcriptional Regulation of CBF-beta
Osteoarthritis (OA) is a degenerative joint disease that involves destruction of articular cartilage and eventually leads to disability. Mesenchymal stem cells (MSCs) reside in healthy and diseased cartilage, and through their chondrogenic potential may provide a strategy for cartilage repair. To th...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-35546 | biostudies-arrayexpress
ProteomicsLocal depletion of proteoglycans mediates cartilage tissue repair in an ex vivo integration model
Successfully replacing damaged cartilage with tissue-engineered constructs requires integration with the host tissue and could benefit from leveraging the native tissue's intrinsic healing capacity; however, efforts are limited by a poor understanding of how cartilage repairs minor defects. Here, we...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-07-18 | PXD035246 | Pride
Proteoglycan depletion Cartilage repair Catabolic enzyme Tissue engineering 
TranscriptomicsMolecular Insight into the Association between Cartilage Regeneration and Ear Wound Healing in Genetic Mouse Models: Targeting New Genes in Regeneration
Certain mouse strains have the ability to heal both ear wounds and knee articular cartilage injuries. A positive genetic correlation between cartilage healing and protection from osteoarthritis exists, which suggests that a common core of genes may operate in healing process. Here, we analyzed knee...
ORGANISM(S): Mus musculus 
2013-07-04 | E-GEOD-48505 | biostudies-arrayexpress
TranscriptomicsDifferential expression analysis of small RNAs in young normal and old osteoarthritis cartilage
Human cartilage taken from young normal knees following anterior cruciate ligament repair and osteoarthritic cartilage following total knee arthroplasty. Total RNA extracted using mirVana miRNA isolation kit (Life Technologies). The Affymetrix Flash Tag labelling kit was used to prepare samples for...
ORGANISM(S): Homo sapiens 
2017-12-31 | E-MTAB-5715 | biostudies-arrayexpress
ProteomicsLocalisation-dependent variations in articular cartilage ECM: implications for tissue engineering and cartilage repair
Articular cartilage (AC) is a specialised connective tissue covering joint surfaces. It enables smooth movement, distributes mechanical loads, and protects the underlying bone. In re-sponse to loading, AC adapts by modifying both its thickness and composition. AC is or-ganised in different zones, wi...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-10-15 | PXD068032 | Pride
Ecm Cartilage Osteoarthritis Pig Proteomcis 
TranscriptomicsDifferential expression analysis of human small RNAs in young normal, old normal (protected)) and old osteoarthritis (unprotected ) knee cartilage
Human cartilage taken from young normal knees following anterior cruciate ligament repair and osteoarthritic cartilage; old normal (protected) and old osteoarthritic (unprotected) following total knee arthroplasty. Total RNA extracted using mirVana miRNA isolation kit (Life Technologies). The Affym...
ORGANISM(S): Homo sapiens 
2017-12-31 | E-MTAB-5716 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis
36 Yucatan minipigs underwent anterior cruciate ligament (ACL) transection and were randomly assigned in equal numbers to no further treatment, reconstruction or ligament repair. Cartilage was harvested at 1 and 4 weeks post-operatively and histology and RNA-sequencing performed. The generated data ...
ORGANISM(S): Sus scrofa 
2017-10-22 | E-MTAB-5879 | biostudies-arrayexpress
UnknownSingle-Surgery Co-Implantation of Autologous Primary Articular Chondrocytes with Bone Marrow Cells in the Treatment of Articular Cartilage Lesions: Observations from the Operating Room on Tissue Input and Cell Output.
Not available
S-EPMC9924989 | biostudies-literature
UnknownComparison Between Arthroscopic and Histological International Cartilage Repair Society Scoring Systems in Porcine Cartilage Repair Model.
Not available
S-EPMC9137296 | biostudies-literature
UnknownConsensus on Rehabilitation Guidelines among Orthopedic Surgeons in the United States following Use of Third-Generation Articular Cartilage Repair (MACI) for Treatment of Knee Cartilage Lesions.
Not available
S-EPMC8808808 | biostudies-literature
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