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ProteomicsClassical virulence factors do not define Cryptococcus pathogenic diversity
Pathogenic determinants in the Cryptococcus genus have been extensively studied, often using standard laboratory isolates. Here, we analyzed the virulence of ten Cryptococcus isolates from diverse sources, species, and genotypes. These isolates exhibited marked differences in their ability to coloni...
ORGANISM(S): Cryptococcus gattii VGII R265 Cryptococcus neoformans var. neoformans JEC21 
2025-10-20 | PXD065863 | Pride
Diversity Virulence Pathogenic Cryptococcus 
ProteomicsProteomic studies on the effects of the deletion of two aminophospholipid translocases in the cellular and extracellular vesicle fractions of Cryptococcus neoformans
Flippases are enzymes responsible for the architecture of eukaryotic membranes, regulating various mechanisms of molecular transport and lipid translocation. In Cryptococcus neoformans, a major fungal pathogen, the aminophospholipid translocase 1 (Apt1) flippase plays roles in fungal virulence, memb...
ORGANISM(S): Cryptococcus neoformans Tu401-MP_1 
2026-06-29 | PXD056961 | Pride
Proteomic deletiontranslocases cellular extracellular vesicle cryptococcus neoformans 
ProteomicsA multi-protease, multi-dissociation, bottom-up-to-top-down proteomic view of the Loxosceles intermedia venom
Venoms are a rich source for the discovery of molecules with biotechnological applications, but their analysis is challenging even for state-of-the-art proteomics. Here we report on a large-scale proteomic assessment of the venom of Loxosceles intermedia, the so-called brown spider. Venom of 200 sp...
ORGANISM(S): Loxosceles intermedia 
2017-05-16 | PXD005523 | Pride
Venom loxosceles intermedia 
MetabolomicsSarcopenic metabolomic profile reflected a sarcopenic phenotype associated with amino acid and essential fatty acid changes

INTRODUCTION: Although sarcopenia greatly affects health and quality of life in older people, its pathophysiological causes are not fully elucidated. To face this challenge, omics technologies can be used. The metabolome gives a vision of the interaction between the genome and t...

2021-09-29 | MTBLS2679 | MetaboLights
UnknownThe C-terminal extension of VgrG4 from Klebsiella pneumoniae remodels host cell microfilaments.
Not available
S-EPMC9542434 | biostudies-literature
ProteomicsProteomics reveals that the antifungal activity of fenbendazole against Cryptococcus neoformans requires protein kinases.
Cryptococcus neoformans is responsible for over 100,000 deaths annually, and the treatment of this fungal disease is expensive and not consistently effective. Unveiling new therapeutic avenues is crucial. Previous studies have suggested that the anthelmintic drug fenbendazole is an affordable and n...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2024-05-21 | PXD047041 | Pride
Cryptococcus neoformans  antifungal activity  fenbendazole  proteomics  protein kinases 
UnknownA population-based screening for hepatitis C antibodies and active infection using a point-of-care test in a low prevalence area.
Not available
S-EPMC7012430 | biostudies-literature
UnknownExternal validation of models to predict hepatocellular carcinoma in Hepatitis C Virus cured F3-F4 patients.
Not available
S-EPMC11497648 | biostudies-literature
UnknownComprehensive Functional Characterization and Clinical Interpretation of 20 Splice-Site Variants of the RAD51C Gene.
Not available
S-EPMC7765170 | biostudies-literature
Unknown<i>RAD51D</i> Aberrant Splicing in Breast Cancer: Identification of Splicing Regulatory Elements and Minigene-Based Evaluation of 53 DNA Variants.
Not available
S-EPMC8201001 | biostudies-literature
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