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TranscriptomicsCoCl2 Response in Cryptococcus neoformans
We investigated the effects of the hypoxia-mimetic CoCl2 on the gene expression of pathogenic fungus Cryptococcus neoformans. Keywords: compound treatment design Three biological repeats were performed using three independent RNA sets isolated from cells cultured on different days and the dye-revers...
ORGANISM(S): Filobasidiella neoformans 
2010-05-19 | E-GEOD-11390 | biostudies-arrayexpress
ProteomicsCryptococcus Wcp1-mCherry Wcp1-FLAG AP–MS
This study aims to identify Wcp1-interacting proteins in Cryptococcus neoformans under different pH conditions. Wcp1 is a WD40–cyclophilin fusion protein implicated in adaptation to host-associated stresses, including CO2, temperature, and acidic pH. Affinity purification coupled with liquid chrom...
ORGANISM(S): Fungi Cryptococcus neoformans H99-YPD_1 
2026-05-16 | PXD077146 | Pride
Wcp1 Cryptococcus Ph 
TranscriptomicsChromosome copy number variation in Cryptococcus neoformans influences virulence and occurs in isolates from AIDS patients
Influence of copy number changes at several chromosomes to melanin production and virulence of Cryptococcus neoformans Black(B4) and white(W2) strains were compared to each other. Black variant from white strain (W2BA1) is also compared to the black strain(B4).
ORGANISM(S): Cryptococcus neoformans 
2011-04-19 | E-GEOD-28673 | biostudies-arrayexpress
TranscriptomicsA defect in iron uptake enhances the susceptibility of Cryptococcus neoformans to azole antifungal drugs.
Transcriptome profiling of wild type and cfo1 mutant with fluconazole treatment in Cryptococcus neoformans var. grubii H99 Purpose: The goals of this study are to compare cfo1 mutant transcriptome profiling (RNA-seq) to wild-type with or without fluconazole treatment in Cryptococcus neoformans var. ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2013-05-31 | E-GEOD-37875 | biostudies-arrayexpress
TranscriptomicsOverexpression of the transcription factor GAT201 in Cryptococcus neoformans var. grubii (serotype A, H99)
Comparison of transcriptional profiles of WT Cryptococcus neoformans (H99) and strain CM126 (pRPL2b-GAT201) which overexpresses the transcription factor GAT201 using a ribosomal protein promoter Keywords: Genetic modification WT vs. CM126 competitive hybridization. 4 biological replicates including...
ORGANISM(S): Filobasidiella neoformans 
2010-05-26 | E-GEOD-10750 | biostudies-arrayexpress
TranscriptomicsThe role of the Ras- and cAMP-signaling pathways in stress response and sterol biosynthesis in Cryptococcus neoformans
The cAMP-pathway plays a central role in regulation of growth, differentiation, and virulence of human pathogenic fungi, including Cryptococcus neoformans. Three major upstream signaling regulators of the adenylyl cyclase (Cac1), Ras, Aca1 (Adenylyl cyclase-associated protein 1) and G-alpha subunit ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-22 | E-GEOD-17338 | biostudies-arrayexpress
TranscriptomicsRemodeling of global transcription patterns of C. neoformans genes mediated by stress-activated HOG signaling pathways
The ability to sense and adapt to a hostile host environment is a crucial element for virulence of pathogenic fungi, including Cryptococcus neoformans. These cellular responses are evoked by diverse signaling cascades, including the stress-activated HOG pathway. Despite previous analysis of centra...
ORGANISM(S): Cryptococcus neoformans var. grubii 
2010-05-17 | E-GEOD-16692 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis of the CO2 sensing pathway via differential expressions of carbonic anhydrase in Cryptococcus neoformans
Carbon dioxide (CO2) sensing, transport, and metabolism play a pivotal role in survival and proliferation of pathogenic microbes infecting human host from natural environments due to the drastic difference of CO2 levels. Carbonic anhydrases (CAs) are not only key CO2-metabolic enzymes catalyzing rev...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-31 | E-GEOD-21192 | biostudies-arrayexpress
TranscriptomicsVanillin derivatives triggers oxidative stress and inhibit mitochondrial functions in Cryptococcus neoformans
Purpose: The purpose of this study is to define the mechanism of antifungal action of the vanillin derivative, o-vanillin, against Cryptococcus neoformans Methods: mRNA profiles of C. neoformasn cells cultured with or without o-vanillin were generated by RNA-Seq, using Illumina GAIIx. The sequence r...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2014-10-22 | E-GEOD-52645 | biostudies-arrayexpress
ProteomicsCryptococcus neoformans treated with different antifungal agents
In this study, we grew cells of Cryptococcus neoformans and treated them with different antifungal agents including CBD and CBDV, a variant form of CBD. Cells were characterised in terms of gross assays, and also at the proteome level. Distinct differences were observed between the different treatme...
ORGANISM(S): Cryptococcus neoformans var. grubii 
2025-04-28 | PXD052384 | Pride
Cryptococcus Anti-gungal 
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