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ProteomicsCryptococcus Wcp1-mCherry Wcp1-FLAG AP–MS
This study aims to identify Wcp1-interacting proteins in Cryptococcus neoformans under different pH conditions. Wcp1 is a WD40–cyclophilin fusion protein implicated in adaptation to host-associated stresses, including CO2, temperature, and acidic pH. Affinity purification coupled with liquid chrom...
ORGANISM(S): Fungi Cryptococcus neoformans H99-YPD_1 
2026-05-16 | PXD077146 | Pride
Wcp1 Cryptococcus Ph 
TranscriptomicsSystematic functional profiling of WD40 proteins reveals Wcp1, a cyclophilin that links CO2/heat tolerance to acidic pH adaptation in Cryptococcus neoformans [RNA-Seq]
WD40 domains are major protein–protein interaction (PPI) scaffolds, yet their contributions to fungal pathogenicity remain poorly defined. We systematically analysed 94 canonical WD40 proteins in Cryptococcus neoformans. Conditional expression and sporulation analyses identified 36 essential WD40 pr...
ORGANISM(S): Cryptococcus neoformans 
2026-05-16 | GSE328123 | GEO
GenomicsSystematic functional profiling of WD40 proteins reveals Wcp1, a cyclophilin that links CO2/heat tolerance to acidic pH adaptation in Cryptococcus neoformans [RNA-Seq]
Systematic functional profiling of WD40 proteins reveals Wcp1, a cyclophilin that links CO2/heat tolerance to acidic pH adaptation in Cryptococcus neoformans [RNA-Seq]
PRJNA1453961 | ENA
UnknownBmlark is essential for embryonic development.
Not available
S-EPMC11619667 | biostudies-literature
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