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UnknownDigital health intervention to <i>opt</i>imise <i>h</i>eart <i>f</i>ailure management after hospital discharge in Brazil (OPT-HF): a randomised clinical trial protocol.
Not available
S-EPMC12007031 | biostudies-literature
UnknownOptimizing heart failure pathways to enhance patient care: the Program to Optimize Heart Failure Patient Pathways (PRO-HF).
Not available
S-EPMC11424341 | biostudies-literature
ProteomicsMulti-omics data integration reveals sex-dependent hippocampal programming by maternal high-fat diet during lactation in adult mouse offspring
Early-life exposure to high-fat diet (HF) can program metabolic and cognitive alterations in adult offspring. Although the hippocampus plays a crucial role in memory and metabolic homeostasis, few studies reported the impact of maternal HF on this structure. We assessed the effects of maternal HF du...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD045639 | Pride
Maternal high-fat diet Multiomics Sexual dimorphism Hippocampus Lc-ms/ms 
TranscriptomicsCardiac gene expression and systemic cytokine profile are complementary in a murine model of post ischemic heart failure
After myocardial infarction (MI) activation of the immune system and inflammatory mechanisms, among others, can lead to ventricular remodeling and heart failure (HF). Interaction between these systemic alterations and corresponding changes in the heart has not been extensively examined in the settin...
ORGANISM(S): Mus musculus 
2010-06-20 | E-GEOD-18703 | biostudies-arrayexpress
ProteomicsPPM1D mutations are oncogenic drivers of de novo Diffuse Midline Glioma formation
Khadka P, Reitman ZJ, Lu S, Buchan G, Gionet G, Dubois F, Carvalho DM, Shih J, Zhang S, Greenwald N, Zack T, Shapira O, Pelton K, Hartley R, Bear H, Georgis Y, Jarmale S, Melanson R, Bonano K, Schoolcraft K, Miller PG, Condurat AL, Gonzalez E, Qian K, Morin E, Langhnoja J, Lupien L, Rendo V, Digiaco...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2021-11-17 | MSV000088404 | MassIVE
UnknownDual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF).
Not available
S-EPMC3746839 | biostudies-literature
UnknownMulti-Omics Data Integration Reveals Sex-Dependent Hippocampal Programming by Maternal High-Fat Diet during Lactation in Adult Mouse Offspring.
Not available
S-EPMC10649590 | biostudies-literature
MetabolomicsViral infection of algal blooms leaves a unique metabolic footprint on the dissolved organic matter in the ocean

Algal blooms are hotspots of primary production in the ocean, forming the basis of the marine food web and fueling the dissolved organic matter (DOM) pool. Marine viruses are key players in controlling algal bloom demise, thereby diverting algal biomass from higher trophic levels to the DOM pool,...

2021-05-05 | MTBLS1720 | MetaboLights
ProteomicsMultiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial
Samples were reduced by the addition of TCEP (25 mM final concentration) and incubated at 37 ºC for 10 min. Alkylation was carried out by the addition of iodoacetamide (25 mM final concentration) and incubated at RT for 1 h in the dark. Samples were then digested by the addition of 1:50 LysC (Wako, ...
ORGANISM(S): Leishmania donovani BPK282A1 
2021-07-18 | PXD023780 | Pride
Thermal proteome profiling Leishmania Oxidosqualene synthase 
ProteomicsThe pterocarpan (+)-PTC mimics microtubule-destabilizing agents by modulating cytoskeletal proteins in metastatic castration-resistant prostate cancer: a proteomic perspective
Treatment of metastatic castration-resistant prostate cancer (mCRPC) remains clinically challenging due to tumor heterogeneity and drug resistance. Microtubule-targeting agents are a mainstay of mCRPC therapy, but limitations persist regarding progression-free survival. Pterocarpans have emerged as ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD073655 | Pride
Prostate cancer Proteomics Cytoskeleton proteins Pterocarpans Microtubule-targeting agents 
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