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MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
MetabolomicsMultiomics analysis of neutrophils in SLE: insights from adult and pediatric disease

Neutrophils contribute to systemic lupus erythematosus (SLE) pathogenesis through ROS and NET production, and increased apoptotic debris which causes autoantibody production and immune complex formation. These processes drive inflammation and tissue damage. The aim of this study was to perform in...

2026-04-22 | MTBLS6259 | MetaboLights
MetabolomicsDeciphering the Anti-Obesity Mechanisms of Pharmabiotic Probiotics through Advanced Multiomics Analysis
Probiotics with 'Pharmabiotic' properties are increasingly recognized as effective tools for combating obesity by altering gut microbiota and reducing body fat. However, the molecular mechanisms underlying their anti-obesity effects remain largely unexplored due to the absence of a universal methodo...
2025-02-20 | MTBLS12185 | MetaboLights
MetabolomicsMultiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health

In order to explore opportunities for personalized and predictive health care, we collected serial clinical measurements, health surveys and multiomics profiles (genomics, proteomics, autoantibodies, metabolomics and gut microbiome) from 96 individuals. The participants underwent data-driven heal...

2021-09-02 | MTBLS2187 | MetaboLights
MetabolomicsMultiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease
We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were foun...
2025-04-25 | MTBLS4332 | MetaboLights
MetabolomicsMultiomics Longitudinal Modeling of Preeclamptic Pregnancies (part II)
Not available
ORGANISM(S): Homo sapiens 
ST001890 | MetabolomicsWorkbench
MetabolomicsMultiomics Longitudinal Modeling of Preeclamptic Pregnancies (part I)
Not available
ORGANISM(S): Homo sapiens 
ST001889 | MetabolomicsWorkbench
MetabolomicsMultiomics of yaks reveals significant contribution of microbiome into host metabolism

BACKGROUND: Grazing yearly on pasture is a traditional practice for yaks, which cannot meet the requirements of yak production since the insufficient forage supplied in the cold season results in a long production cycle. An intensive feeding system increasing production efficiency has been select...

2024-10-01 | MTBLS10450 | MetaboLights
MetabolomicsMultiomics analysis of residual feed intake regulation in calves by intestinal microbiota-mediated epigenetic modifications
Feed efficiency is a critical trait affecting the economic profitability and environmental sustainability of livestock production. Residual Feed Intake (RFI), as a key metric for feed efficiency, effectively reflects differences in energy utilization for maintenance and production. This study aims t...
2026-04-20 | MTBLS14315 | MetaboLights
MetabolomicsThe integration of network pharmacology and multiomics reveals the mechanism by which Malus hupehensis leaves inhibit acute liver injury

Objective: The leaves of Malus hupehensis (MH) are a medicinal and edible traditional Chinese medicine (TCM) with good liver protection, although its underlying mechanism remains unclear. In this study, a network pharmacology-integrated multi-omics method was used to explore the hepatoprotective ...

2026-05-01 | MTBLS13219 | MetaboLights
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