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TranscriptomicsRNA sequencing (RNA-SEQ) of Dnmt1 and Dnmt3a conditional knockout mice
Purpose: Epigenetic regulation contributes to pathogenesis of neurondegenerative disease. We found that dis-regulation of a 242-gene subnetwork related to DNA methylation regulated neuronal differentiation are common in AD and HD. There are two DNA methyltransferases, DNMT1 and DNMT3A, in the subn...
ORGANISM(S): Mus musculus 
2014-07-31 | E-GEOD-58261 | biostudies-arrayexpress
TranscriptomicsMultiple sclerosis patient-derived CSF induces transcriptional changes in proliferating oligodendrocyte progenitors
This study provides an overview of the transcriptional signature of oligodendrocyte progenitor cells (OPCs) exposed to the CSF collected from multiple sclerosis patients with either a relapsing remitting disease course (RRMS) or a confirmed primary progressive diagnosis (PPMS). Using an Affymetrix ...
ORGANISM(S): Rattus norvegicus 
2015-06-19 | E-GEOD-60881 | biostudies-arrayexpress
ProteomicsPRMT5 interacting partners and substrates in oligodendrocyte lineage cells
The protein arginine methyl transferase PRMT5 is an enzyme expressed in oligodendrocyte lineage cells and responsible for the symmetric methylation of arginine residues on histone tails. Previous work from our laboratory identified PRMT5 as critical for myelination, due to its transcriptional regula...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-11-16 | MSV000088396 | MassIVE
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