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TranscriptomicsSingle-cell Atlas of intrahepatic T cells reveals a population of liver-resident naive-like CD4+ T cells expanded in primary sclerosing cholangitis
The composition of intrahepatic immune cells in primary sclerosing cholangitis (PSC) and their contribution to disease pathogenesis is widely unknown. We here generated a single-cell atlas of intrahepatic T cells in PSC, a type of immune cells that has previously been involved in the pathogenesis of...
ORGANISM(S): Homo sapiens 
2021-03-27 | E-MTAB-10143 | biostudies-arrayexpress
TranscriptomicsInflammatory type 2 conventional dendritic cells contribute to murine and human cholangitis
Cholangitis mouse models were characterised by selective intrahepatic expansion of type 2 conventional dendritic cells, whereas plasmacytoid and type 1 conventional dendritic cells were not expanded. Expansion of type 2 conventional dendritic cells in human PSC lesions was confirmed by histology. De...
ORGANISM(S): Mus musculus 
2022-07-08 | E-MTAB-11821 | biostudies-arrayexpress
TranscriptomicsThe identity of the apoptotic cell explains the functional diversity of the efferocytic macrophages
Macrophages are a functionally heterogeneous cell population, critical for the clearance of apoptotic cells. Apoptotic cells have so far been regarded as cells with homogeneous characteristics, often neglecting their original cell lineage identity. Contrary to this, we have observed that the identit...
ORGANISM(S): Mus musculus 
2024-02-16 | E-MTAB-13753 | biostudies-arrayexpress
TranscriptomicsNKp44/HLA-DP-dependent regulation of CD8 T cell clonality by NK cells
NK cells are increasingly recognized for their modulation of adaptive T cell responses; however the mechanisms by which NK cells modulate immune responses in human are unclear. Here we report that NKp44+ NK cells regulate CD8+ T cell expansion in an HLA-DP haplotype-dependent process. HLA-DP express...
ORGANISM(S): Homo sapiens 
2025-10-10 | E-MTAB-13405 | biostudies-arrayexpress
TranscriptomicsIntergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis
We correlated comprehensive T cell phenotyping data from peripheral blood to the corresponding genotype of different disease-associated and T cell related SNPs. This revealed significantly increased frequencies of naive CD4+ T cells (CD4+ TN) and T helper 17 (TH17) cells in carriers of intergenic SN...
ORGANISM(S): Homo sapiens 
2024-05-22 | E-MTAB-14103 | biostudies-arrayexpress
TranscriptomicsIntergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis
We correlated comprehensive T cell phenotyping data from peripheral blood to the corresponding genotype of different disease-associated and T cell related SNPs. This revealed significantly increased frequencies of naive CD4+ T cells (CD4+ TN) and T helper 17 (TH17) cells in carriers of intergenic SN...
ORGANISM(S): Homo sapiens 
2024-04-22 | E-MTAB-14013 | biostudies-arrayexpress
TranscriptomicsThe identity of the apoptotic cell explains the functional diversity of the efferocytic macrophages
Macrophages are a functionally heterogeneous cell population, critical for the clearance of apoptotic cells. Apoptotic cells have so far been regarded as cells with homogeneous characteristics, often neglecting their original cell lineage identity. Contrary to this, we have observed that the identit...
ORGANISM(S): Mus musculus 
2024-02-16 | E-MTAB-13780 | biostudies-arrayexpress
UnknownEarly heme oxygenase 1 induction delays tumour initiation and enhances DNA damage repair in liver macrophages of Mdr2-/- mice.
Not available
S-EPMC6214975 | biostudies-literature
UnknownGender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals.
Not available
S-EPMC11367877 | biostudies-literature
UnknownIntergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis.
Not available
S-EPMC11293351 | biostudies-literature
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