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ModelsRodriguez-Caso2006_Polyamine_Metabolism
SBML creators: Armando Reyes-Palomares * , Carlos Rodríguez-Caso +, Raul Montañez * , Marta Cascante $, Francisca Sánchez-Jiménez * , Miguel A. Medina * * ProCel Group, Department of Molecular Biology and Biochemistry, Faculty of Sciences, Campus de Teatinos, University o...
2024-09-02 | BIOMD0000000190 | BioModels
MetabolomicsMaslinic acid-enriched diet decreases intestinal tumorigenesis in Apc(Min/+) mice through transcriptomic and metabolomic reprogramming
Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and indu...
2017-02-09 | MTBLS240 | MetaboLights
TranscriptomicsRNA Affymetrix microarray analysis of colonic mucosal layer of Apc Min/+ mice fed or not with maslinic acid.
This experiment reports the RNA microarray data from the microarray analysis performed to the RNA isolated from colonic mucosal layer of Apc Min/+ mice. Apc Min/+ mice develop polyps in both the small and large intestine, with a greater incidence of intestinal adenomas observed in the former. We wan...
ORGANISM(S): Mus musculus 
2015-10-31 | E-MTAB-4007 | biostudies-arrayexpress
MetabolomicsThe effects of oligomycin administration and glutamine deprivation on metabolic profile of MCF7 breast cancer cell line measured using [1,2-13C2]-D-glucose and [U-13C5]-L-glutamine as tracers
This study aims to establish a comprehensive, genome-scale metabolic model (GSMM) combining different omics data of different regulatory levels of breast cancer cells in order to elucidate the way that these regulatory levels affect or determine each other. Together with transcriptomics, proteomics ...
2021-01-18 | MTBLS183 | MetaboLights
ModelsOrtega2006 - bistability from double phosphorylation in signal transduction
Ortega2006 - bistability from double phosphorylation in signal transduction This model is described in the article: Bistability from double phosphorylation in signal transduction. Kinetic and structural requirements. Ortega F, Ga...
2024-09-02 | BIOMD0000000258 | BioModels
ModelsCurto1998 - purine metabolism
Curto1998 - purine metabolism This is a purine metabolism model that is geared toward studies of gout. The model uses Generalized Mass Action (GMA; i.e. power law) descriptions of reaction rate laws. Such descriptions are local approximations that assume indepe...
2024-09-02 | BIOMD0000000015 | BioModels
MetabolomicsIsotopomer analysis of MCF-7 breast cancer cell line incubated with 13C labelled glucose (GC-MS assay)
MS and NMR are two of the most powerful spectroscopic techniques used in the field of fluxomics, to analyze the flux distributions in cellular metabolomic pathways. Both of them possess pros and cons, such as, MS being the most sensitive and low-cost technique, while needs extensive sample processin...
2018-05-02 | MTBLS182 | MetaboLights
MetabolomicsIsotopomer analysis of MCF-7 breast cancer cell line incubated with 13C labelled glucose (NMR assay)
MS and NMR are two of the most powerful spectroscopic techniques used in the field of fluxomics, to analyze the flux distributions in cellular metabolomic pathways. Both of them possess pros and cons, such as, MS being the most sensitive and low-cost technique, while needs extensive sample processin...
2018-05-02 | MTBLS241 | MetaboLights
MetabolomicsStable isotope resolved analysis of HUVEC Cells under normaxia and hypoxia
In order to analyze HUVECs under normoxia and hypoxia, cells were initially deprived of excess nutrients and hormones by maintaining them overnight in a restricted medium with only 2% fetal bovine serum, and incubated for 40 hours in the presence of the tracer [1,2-13C2]-glucose until sample collect...
2017-12-18 | MTBLS412 | MetaboLights
MetabolomicsPlasma metabolic profile in COPD patients: effects of exercise and endurance training
The study examines plasma metabolic profiles of patients with chronic obstructive pulmonary disease (COPD) to prove whether the disease influences metabolism at rest and after endurance training. This is based on the hypothesis that metabolome levels should reflect impaired skeletal muscle bioenerge...
2017-03-10 | MTBLS249 | MetaboLights
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