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TranscriptomicsExpression data from the aortas of ApoE knockout, ApoE/Caspase-1 double knockout, and wild-type mice
Caspase-1 activation senses metabolic danger-associated molecular patterns and mediates the initiation of inflammation. Here, we reported that caspase-1 contributes to hyperlipidemia-induced modulation of vascular cell gene expression during early atherosclerosis in vivo. Our results demonstrate the...
ORGANISM(S): Mus musculus 
2015-08-21 | E-GEOD-72248 | biostudies-arrayexpress
ProteomicsMapping the Binding Interactions Between human Gasdermin D and human Caspase-1 Using Carbene Footprinting
Carbene footprinting is a recently developed mass spectrometry-based chemical labeling technique that probes protein interactions and conformation. Here, we use the methodology to investigate binding interactions between the protease human Caspase-1 (C285A) and full-length human Gasdermin D (hGSDMD)...
ORGANISM(S): Homo sapiens (Human) 
2023-08-14 | PXD040212 | Pride
Gsdmd Footprinting Lc-ms Interaction Caspase-1 
TranscriptomicsCaspase-1 deficiency reduces intestinal and hepatic triglyceride-rich lipoprotein secretion
Background and Aims: Inflammasome-mediated caspase-1 activity regulates the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1M-CM-^_ and IL-18. Recently, we showed that caspase-1 deficiency strongly reduces high fat diet-induced adiposity although the mechanism is still unc...
ORGANISM(S): Mus musculus 
2013-09-15 | E-GEOD-32515 | biostudies-arrayexpress
GenomicscFLIP suppresses Caspase-1- and MLKL-independent perinatal lethality driven by autoprocessing impaired caspase-8 D387A
cFLIP suppresses Caspase-1- and MLKL-independent perinatal lethality driven by autoprocessing impaired caspase-8 D387A
PRJNA1275685 | ENA
TranscriptomicsIRF2 regulates macrophages apoptosis through a STAT1/3 and Caspase-1-dependent mechanism
Using microarray gene expression profiling of liver RNA samples rerived from IRF2+/+ and IRF2-/- mice treated with saline or LPS, we identified >40 genes that were significantly down-regulated in IRF2 -/- mice, including STAT3 which has been reported to regulate apoptosis. Keywords: compound treatme...
ORGANISM(S): Mus musculus 
2007-09-01 | E-GEOD-5907 | biostudies-arrayexpress
GenomicsCaspase-1 from Human Myeloid Derived Suppressor Cells Can Promote T-cell independent Tumor Proliferation
Caspase-1 from Human Myeloid Derived Suppressor Cells Can Promote T-cell independent Tumor Proliferation
PRJNA447932 | ENA
GenomicsTranscriptional profilling of In vitro-primed C.rodentium-specific WT or Caspase-1 deficient Th cells
Transcriptional profilling of In vitro-primed C.rodentium-specific WT or Caspase-1 deficient Th cells
PRJNA591907 | ENA
GenomicsIL-1β sensitizes to atrial fibrillation acting through resident macrophages and caspase-1 expression
IL-1β sensitizes to atrial fibrillation acting through resident macrophages and caspase-1 expression
PRJNA1198111 | ENA
TranscriptomicsCaspase-1 deficiency reduces intestinal and hepatic triglyceride-rich lipoprotein secretion
Background and Aims: Inflammasome-mediated caspase-1 activity regulates the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1ß and IL-18. Recently, we showed that caspase-1 deficiency strongly reduces high fat diet-induced adiposity although the mechanism is still unclear. ...
ORGANISM(S): Mus musculus 
2013-09-15 | GSE32515 | GEO
TranscriptomicscFLIP suppresses Caspase-1- and MLKL-independent perinatal lethality driven by autoprocessing impaired caspase-8 D387A
Death ligands, including FAS ligand (FASL) and tumor necrosis factor (TNF), trigger apoptosis by promoting caspase-8 dimerization and activation. Impaired FAS signaling causes unconventional lymphocytes to accumulate, resulting in lymphadenopathy. Although autoprocessing of caspase-8 is considered i...
ORGANISM(S): Mus musculus 
2025-11-10 | GSE299620 | GEO
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