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UnknownStructural basis for mTORC1 regulation by the CASTOR1-GATOR2 complex.
Not available
S-EPMC12477443 | biostudies-literature
UnknownRNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.
Not available
S-EPMC7887217 | biostudies-literature
UnknownSeeking mTORC1 Inhibitors Through Molecular Dynamics Simulation of Arginine Analogs Inhibiting CASTOR1.
Not available
S-EPMC6885358 | biostudies-literature
UnknownMechanism of arginine sensing by CASTOR1 upstream of mTORC1.
Not available
S-EPMC4988899 | biostudies-literature
UnknownStructural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway.
Not available
S-EPMC5187391 | biostudies-literature
UnknownStructural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling.
Not available
S-EPMC5020642 | biostudies-literature
Unknown<i>CASTOR1</i>: A Novel Tumor Suppressor Linking mTORC1 and KRAS Pathways in Tumorigenesis and Resistance to KRAS-Targeted Therapies in Non-Small Cell Lung Cancer.
Not available
S-EPMC12045348 | biostudies-literature
UnknownCASTOR1 phosphorylation predicts poor survival in male patients with KRAS-mutated lung adenocarcinoma.
Not available
S-EPMC11465729 | biostudies-literature
ProteomicsDifferential cell survival outcomes in response to diverse amino acid stress
Mammalian cells respond to amino acid limitation by activating a coordinated response to preserve cell function and resources. Here we dissected amino acid stress sensing and adaptation and examined how prolonged arginine or leucine starvation alters cellular behavior of murine embryonic stem cells,...
ORGANISM(S): Mus musculus (Mouse) Saccharomyces cerevisiae (Baker's yeast) 
2025-04-01 | PXD030959 | Pride
Post-translational modification Proteomics Stress Phosphoproteomics Tube-ms Ap-ms Ubiquitinomics Castor1 Phosphorylation Protein-protein interaction Amino acid starvation Sesn2 Mtor 
UnknownThe CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.
Not available
S-EPMC4808398 | biostudies-literature
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