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Ribonucleoprotein complexes are dynamic assemblies of RNA associated with RNA-binding proteins (RBPs), which can modulate the fate of the RNA molecules from transcription to degradation. Dysregulation of RBPs is linked to diseases such as cancer and neurological disorders, which motivated the develo...
ORGANISM(S): Homo sapiens (Human) 
2025-02-25 | PXD056233 | Pride
We investigated RNAs involved in the maintenance of spatial chromatin organization during interphase. Various RNA fractions from HeLa cells were prepared, tested in in vivo experiments and sequenced in order to identify and characterize the RNA fraction presenting the higher activity.
ORGANISM(S): Homo sapiens 
We have isolated, analyzed and compared the RNA content of various cell compartments including total RNA, nucleolplasmic RNA and nucleolar RNA. In addition, cells have been subjected to various treatment to specifically inhibit each of the RNA polymerases I, II and III, as well as protein synthesis...
ORGANISM(S): Homo sapiens 
We have develop a simple fact method to isolate transcription factories and analyzed their RNA content as compared to total poly(A)+ and chromatin associated RNA fractions in presence or absence of pro-inflammatory cytokine.
ORGANISM(S): Homo sapiens 
Investigation of RNA-dependent proteins in the yeasts S.pombe and S.cerevisiae by using density gradient ultracentrifugation combined with mass spectrometry. The data consisted of three independent biological replicates of the corresponding wild-type strains. The analysis includes both a control gro...
ORGANISM(S): Schizosaccharomyces pombe 927 Saccharomyces cerevisiae (Baker's yeast) 
2026-07-23 | PXD058607 | Pride
We determined genome-wide nucleosome occupancy in mouse embryonic stem cells and their neural progenitor and embryonic fibroblast counterparts to assess features associated with nucleosome positioning during lineage commitment. Cell type and protein specific binding preferences of transcription fact...
ORGANISM(S): Mus musculus 
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