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MetabolomicsIn-depth characterization of the CaV2.2-knockout mouse line

ABSTRACT The voltage-gated calcium channel CaV2.2 is predominantly located in neuronal synapses, where it plays a role in pain signaling and neurotransmitter release. Furthermore, CaV2.2 is important during early central nervous system development, as it is subsequently replaced by other calcium ...

2026-07-09 | MTBLS14319 | MetaboLights
ProteomicsCAV2-expressing Nerves induce Metabolic Switch toward Mitochondrial Oxidative Phosphorylation to Promote Cancer Stemness
Cancer cells and the nervous system engage in a dynamic interplay, significantly influencing initiation and progression in head and neck squamous cell carcinoma (HNSCC). Our findings highlight that cancer cells drive an increase in caveolin-2 (Cav2) expression within trigeminal ganglia and associate...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-04 | PXD060212 | Pride
Cav2  cancer neuroscience  perineural invasion  oxidative phosphorylation cancer stemness 
GenomicsCAV2-expressing Nerves induce Metabolic Switch toward Mitochondrial Oxidative Phosphorylation to Promote Cancer Stemness
CAV2-expressing Nerves induce Metabolic Switch toward Mitochondrial Oxidative Phosphorylation to Promote Cancer Stemness
PRJNA1219051 | ENA
TranscriptomicsCAV2-expressing Nerves induce Metabolic Switch toward Mitochondrial Oxidative Phosphorylation to Promote Cancer Stemness
Cancer cells and the nervous system engage in a dynamic interplay, significantly influencing initiation and progression in head and neck squamous cell carcinoma (HNSCC). Our findings highlight that cancer cells drive an increase in caveolin-2 (Cav2) expression within trigeminal ganglia and associate...
ORGANISM(S): Homo sapiens 
2025-02-04 | GSE288675 | GEO
UnknownPrognostic Value of CAV1 and CAV2 in Head and Neck Squamous Cell Carcinoma.
Not available
S-EPMC9952890 | biostudies-literature
UnknownQuantitative proteomics of the Cav2 channel nano-environments in the mammalian brain.
Not available
S-EPMC2930569 | biostudies-literature
UnknownCAV2-expressing nerves induce metabolic switch toward mitochondrial oxidative phosphorylation to promote cancer stemness.
Not available
S-EPMC12780207 | biostudies-literature
UnknownCAV2 promotes the invasion and metastasis of head and neck squamous cell carcinomas by regulating S100 proteins.
Not available
S-EPMC9481523 | biostudies-literature
UnknownExpression-associated polymorphisms of CAV1-CAV2 affect intraocular pressure and high-tension glaucoma risk.
Not available
S-EPMC4431411 | biostudies-literature
UnknownCaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles.
Not available
S-EPMC10023163 | biostudies-literature
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