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ProteomicsInvestigating Synthetic Lethality and PARP Inhibitor Resistance in Pancreatic Cancer Through Enantiomer Differential Activity
The RAD51-BRCA2 interaction is central to DNA repair through homologous recombination. Emerging evidence indicates RAD51 overexpression and its correlation with chemoresistance in various cancers, suggesting RAD51-BRCA2 inhibition as a compelling avenue for intervention. We previously showed that co...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054120 | Pride
Anticancer drugs  homologous recombination  parp inhibitors  protein-protein small molecule inhibitors  parpi resistance  within-pathway synthetic lethality (wpsl) 
UnknownDual-Functional Nano-Functionalized Titanium Scaffolds to Inhibit Bacterial Growth and Enhance Osteointegration.
Not available
S-EPMC8537418 | biostudies-literature
UnknownDissecting the RAD51-BRC4 Interaction Landscape through Integrative Molecular Simulations and Experimental Biophysics.
Not available
S-EPMC12606624 | biostudies-literature
ProteomicsDissecting the RAD51–BRC4 Interaction Landscape through Integrative Molecular Simulations and Experimental Biophysics
The interaction between the RAD51 and BRCA2 proteins is central to homologous recombination (HR), a crucial pathway ensuring high-fidelity DNA repair. Recruitment of RAD51 involves eight highly conserved regions on BRCA2, named BRC repeats. The interaction between the fourth BRC repeat (BRC4) and th...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-10-29 | PXD060867 | Pride
UnknownIdentification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry.
Not available
S-EPMC9377020 | biostudies-literature
UnknownPopulation genetic implications from sequence variation in four Y chromosome genes.
Not available
S-EPMC16549 | biostudies-literature
UnknownSynthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib.
Not available
S-EPMC7997579 | biostudies-literature
UnknownInvestigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity.
Not available
S-EPMC11911456 | biostudies-literature
UnknownTargeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability.
Not available
S-EPMC4833192 | biostudies-literature
UnknownObservation of quantum entanglement with top quarks at the ATLAS detector.
Not available
S-EPMC11410654 | biostudies-literature
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