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ProteomicsDiscovery proteomics studies for the identification of a protein panel associated with the response to pemetrexed in platinum drug resistant cancer
Pemetrexed is a drug largely used in lung cancer, mesothelioma and proposed in some cases of ovarian cancers, a particularly severe cancer type. In this latest tumor type, therapy relies on debulking surgery and platinum-based chemotherapy. Despite the initial high response rates to platinum drugs, ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD007056 | Pride
Platinum drug resistance Lc ms/ms Ovarian cancer Discovery proteomics 
ModelsBesozzi2012 - Oscillatory regimes in the Ras/cAMP/PKA pathway in S.cerevisiae
Besozzi2012 - Oscillatory regimes in the Ras/cAMP/PKA pathway in S.cerevisiae Mechanistic model of the Ras/cAMP/PKA in yeast S.cerevisiae. The Ras/cAMP/PKA pathway plays a major role in the regulation of metabolism, stress resistance and cell cycle progress and is tightly regulated...
2024-09-02 | BIOMD0000000478 | BioModels
TranscriptomicsRNA-seq of human breast epithelial cell line MCF10A treated for 8 days with the CDC7 inhibitors XL413, TAK-931 against DMSO-treated controls
CDC7 is a serine-threonine kinase, which has an important role in the activation of replication origins in the S-phase. CDC7 is also a potential molecular target for the development of anticancer drugs. Multiple studies have shown that different cell lines have a wide range of sensitivity to CDC7 i...
ORGANISM(S): Homo sapiens 
2024-05-14 | E-MTAB-13179 | biostudies-arrayexpress
UnknownPrognostic effect of circulating adiponectin in a randomized 2 x 2 trial of low-dose tamoxifen and fenretinide in premenopausal women at risk for breast cancer.
Not available
S-EPMC3255561 | biostudies-literature
UnknownA Controlled, Retrospective, Single-Center Study to Evaluate the Role of a Probiotic Mixture Administered during Pregnancy in Reducing Streptococcus Agalactiae Swab Positivity and the Frequency of Premature Rupture of Amniochorionic Membranes.
Not available
S-EPMC11509217 | biostudies-literature
MetabolomicsComparing Campylobacter jejuni to three other enteric pathogens in OligoMM 12 mice reveals pathogen-specific host and microbiota responses
Campylobacter jejuni, non-typhoidal Salmonella spp., Listeria monocytogenes and enteropathogenic/enterohemorrhagic Escherichia coli (EPEC/EHEC) are leading causes of food-borne illness worldwide. Citrobacter rodentium has been used to model EPEC and EHEC infection ...
2025-02-25 | MTBLS11078 | MetaboLights
UnknownIn vivo and in silico analysis of PCNA ubiquitylation in the activation of the Post Replication Repair pathway in S. cerevisiae.
Not available
S-EPMC3668150 | biostudies-literature
UnknownStudy to evaluate the safety and tolerability of <i>Streptococcus salivarius</i> eK12, a genetically modified strain derived from the oral probiotic S. <i>salivarius</i> K12: Results from a randomized, double-blind, placebo-controlled, parallel-group clinical trial.
Not available
S-EPMC12719284 | biostudies-literature
UnknownModeling Calcium Signaling in S. cerevisiae Highlights the Role and Regulation of the Calmodulin-Calcineurin Pathway in Response to Hypotonic Shock.
Not available
S-EPMC9158465 | biostudies-literature
ModelsAmara2013 - PCNA ubiquitylation in the activation of PRR pathway
Mechanistic model of the Post-Replication Repair (PRR), the pathway involved in the bypass of DNA lesions induced by sunlight exposure and UV radiation. PRR acts through two different mechanisms, activated by mono- and poly-ubiquitylation of the DNA sliding clamp, called Proliferating Ce...
2024-09-02 | BIOMD0000000475 | BioModels
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