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ProteomicsMapping the protein-protein interaction interface between recombinant CB1R and GlyT2 using cross-linking mass spectrometry
This project aims to elucidate a novel molecular mechanism driving mechanical allodynia, a debilitating neuropathic pain condition. We focus on a spinal cord “allodynia gate” circuit in which nerve injury leads to disinhibition of protein kinase Cγ (PKCγ) excitatory neurons. Our findings reveal that...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD070478 | Pride
Cb1r protein Cx-ms Glyt2 protein 
UnknownCannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cells.
Not available
S-EPMC4332989 | biostudies-literature
UnknownCB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity.
Not available
S-EPMC9225989 | biostudies-literature
UnknownInterference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos.
Not available
S-EPMC6982252 | biostudies-literature
UnknownThe CB1R rs2023239 receptor gene variant significantly affects the reinforcing effects of nicotine, but not cue reactivity, in human smokers.
Not available
S-EPMC7882168 | biostudies-literature
UnknownCB1R regulates CDK5 signaling and epigenetically controls Rac1 expression contributing to neurobehavioral abnormalities in mice postnatally exposed to ethanol.
Not available
S-EPMC6333777 | biostudies-literature
UnknownA role of CB1R in inducing θ-rhythm coordination between the gustatory and gastrointestinal insula.
Not available
S-EPMC5007515 | biostudies-literature
UnknownIn silico analyses of the involvement of GPR55, CB1R and TRPV1: response to THC, contribution to temporal lobe epilepsy, structural modeling and updated evolution.
Not available
S-EPMC10894036 | biostudies-literature
ProteomicsSH-SY5Y_CB1R-antagonist_Proteomics
Cannabinoid receptor type 1 (CB1R) is one of the most abundant GPCRs in the brain, playing a critical role in neuronal viability. While CB1R activation is typically associated with neuroprotective effects, excessive or prolonged activation can be adverse. CB1R antagonists, therefore, have shown neur...
ORGANISM(S): Homo Sapiens (human) 
2024-12-03 | PXD058518 | JPOST Repository
UnknownCannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.
Not available
S-EPMC4366794 | biostudies-literature
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