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ProteomicsThe cross-linking mass spectrometry (CX-MS) results of Human TIP60 complex (hTIP60)
Mammalian TIP60 is a multi-functional enzyme with histone acetylation and histone dimer exchange activities. It plays roles in diverse cellular processes including transcription, DNA repair, cell cycle control, and embryonic development. We performed structural study on human TIP60 complex with cryo...
ORGANISM(S): Homo sapiens (Human) 
2024-07-11 | PXD048625 | Pride
Human Tip60 Cx-ms 
UnknownValidation of an LC-MS/MS Method for the Quantification of the CK2 Inhibitor Silmitasertib (CX-4945) in Human Plasma.
Not available
S-EPMC9028559 | biostudies-literature
UnknownLC-MS/MS method for quantitation of the CK2 inhibitor silmitasertib (CX-4945) in human plasma, CSF, and brain tissue, and application to a clinical pharmacokinetic study in children with brain tumors.
Not available
S-EPMC7484447 | biostudies-literature
ProteomicsThe CX-MS-based quantifitative proteomic analysis of interactome of plant nucleus
To profile the interactome of cell nucleus,a formaldehyde-CBDPS double chemical-crosslinking method was combined with mass spectrometry to perform quantitative interactomics on the in vivo fixed nuclei.
ORGANISM(S): Glycine max 
2023-05-10 | PXD034796 | Pride
Lc-ms/ms Nucleus Nucleome Interactome Chemical crosslinking Quantitative interactomics Dimethyl labelling 
ProteomicsMolecular architecture of the augmin complex
Haus DSSO CX-MS analysis to validate Cyro-EM analysis of Haus multimer
ORGANISM(S): Homo sapiens (Human) 
2022-06-29 | PXD031411 | Pride
Augmin complex Haus Cx-ms 
ProteomicsAnalysis of conformational changes induced by binding of allosteric nanobodies to a bacterial LRRK2 homologue by CX-MS
As part of an in-depth characterization of nanobodies directed against the Chlorobium tepidum protein CtRoco, a bacterial LRRK2 homologue, chemical crosslinking combined with mass spectrometry (CX-MS) was performed. Two allosteric nanobodies binding to two different epitopes in the LRR and the Roc d...
ORGANISM(S): Chlorobium tepidum 
2024-04-23 | PXD046634 | Pride
Lrrk2 Dsso Nanobodies Crosslinking Ctroco 
ProteomicsStructural study of human MRE11-RAD50-NBS1 (MRN) complex by crosslinking mass spectrometry
A chemical crosslinking-mass spectrometry (CX-MS) experiment was performed to study the structure of the human MRN complex in the presence of ATM and DNA.
ORGANISM(S): Homo sapiens (Human) 
2025-08-13 | PXD067324 | Pride
Cx-ms Mrn complex 
ProteomicsThe catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1
T-Cell Protein Tyrosine Phosphatase (TCPTP, PTPN2) is a non-receptor type protein tyrosine phosphatase that is ubiquitously expressed in human cells. TCPTP is a critical component of a variety of key signaling pathways that are directly associated with the formation of cancer and inflammation. Thus,...
ORGANISM(S): Homo sapiens (Human) 
2021-11-10 | PXD029256 | Pride
Tcptp Ptpn2 Intermolecular cx-ms Intramolecular cx-ms 
TranscriptomicsIdentification of miRNAs that mediate protective function of anti-cancer drugs during white matter ischemic injury
Anti-cancer drugs, CX-4945 and MS-275 provide protection to white matter injury in part through miRNAs expression regulation. Optic_nerve_nanostring_file_Raw_Data.xls
ORGANISM(S): Mus musculus 
2021-04-07 | GSE171568 | GEO
ProteomicsMapping the protein-protein interaction interface between recombinant CB1R and GlyT2 using cross-linking mass spectrometry
This project aims to elucidate a novel molecular mechanism driving mechanical allodynia, a debilitating neuropathic pain condition. We focus on a spinal cord “allodynia gate” circuit in which nerve injury leads to disinhibition of protein kinase Cγ (PKCγ) excitatory neurons. Our findings reveal that...
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD070478 | Pride
Cb1r protein Cx-ms Glyt2 protein 
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