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ProteomicsThe catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1
T-Cell Protein Tyrosine Phosphatase (TCPTP, PTPN2) is a non-receptor type protein tyrosine phosphatase that is ubiquitously expressed in human cells. TCPTP is a critical component of a variety of key signaling pathways that are directly associated with the formation of cancer and inflammation. Thus,...
ORGANISM(S): Homo sapiens (Human) 
2021-11-10 | PXD029256 | Pride
Tcptp Ptpn2 Intermolecular cx-ms Intramolecular cx-ms 
ProteomicsThe phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR
The protein tyrosine phosphatases (PTPs) TCPTP, PTPN22, and SHP1 are critical regulators of the activating phophotyrosine (pY) site on the initiating T cell kinase, LckY394, but the broader implications of these phophatases in T cell receptor (TCR) signalling and T cell biology remain unclear. By co...
ORGANISM(S): Homo sapiens (Human) 
2025-08-01 | PXD058624 | Pride
Shp1 Phosphoproteomics Tcptp Ptpn22 T cell signaling 
UnknownElevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.
Not available
S-EPMC3263335 | biostudies-literature
UnknownThe catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1.
Not available
S-EPMC8748766 | biostudies-literature
UnknownBiophysical Rationale for the Selective Inhibition of PTP1B over TCPTP by Nonpolar Terpenoids.
Not available
S-EPMC10694825 | biostudies-literature
UnknownA biophysical rationale for the selective inhibition of PTP1B over TCPTP by nonpolar terpenoids.
Not available
S-EPMC10153121 | biostudies-literature
UnknownThe phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR.
Not available
S-EPMC12311025 | biostudies-literature
UnknownLong non-coding RNA TINCR promotes hepatocellular carcinoma proliferation and invasion via STAT3 signaling by direct interacting with T-cell protein tyrosine phosphatase (TCPTP).
Not available
S-EPMC8806792 | biostudies-literature
UnknownMapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes.
Not available
S-EPMC12790674 | biostudies-literature
UnknownThe Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease.
Not available
S-EPMC9854873 | biostudies-literature
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