The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease.
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ABSTRACT:
SUBMITTER: Nguyen Huu T
PROVIDER: S-EPMC9854873 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
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The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease.
Nguyen Huu Thang T Park Jiyoung J Zhang Ying Y Duong Thanh Hien H Park Iha I Choi Jin Myung JM Yoon Hyun Joong HJ Park Sang Chul SC Woo Hyun Ae HA Lee Seung-Rock SR
Antioxidants (Basel, Switzerland) 20230103 1
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are becoming increasingly prevalent worldwide. Despite the different etiologies, their spectra and histological feature are similar, from simple steatosis to more advanced stages such as steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Studies including peroxiredoxin knockout models revealed that oxidative stress is crucial in these diseases, which present as consequences of redox imbalance. Protein tyr ...[more]
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