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ProteomicsHDX-MS analysis of PTPN2 with the CRBN/DDB1 complex
We used HDX-MS analysis to analyze the interaction between PTPN2 with a compound both in the presence and absence of the CRBN/DDB1 complex. We identified significant changes in HDX when PTPN2 was in the presence of compound. We also identified significant changes when comparing the deuteration profi...
ORGANISM(S): Homo sapiens (Human) 
2024-08-23 | PXD053867 | Pride
Hdx-ms Ptpn2 Crbn Ddb1 
ProteomicsTyrosine-protein phophatase non-receptor type 2 (PTPN2) deficiency increases short-lived effector T-cell survival and augments autonomous proliferation of T-cells
Whole proteome and phosphoproteome analysis of T-cells isolated from PTPN2 wild-type and knock-out micestrongly linked amplified T cell numbers to increased proliferation mediated by transcriptional activation of the signal transducer and activator of transcription (STAT) protein family. Subsequent ...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-29 | PXD013122 | Pride
T-cells Ms3 Tmt Ptpn2 Phosphoproteomics 
GenomicsPTPN2 knockout vs WT
PTPN2 knockout vs WT
PRJNA871237 | ENA
GenomicsCytokine Stimulation of PTPN2-deleted cancer cells
Cytokine Stimulation of PTPN2-deleted cancer cells
PRJNA388068 | ENA
TranscriptomicsDifferential gene expression in WT mice and mice lacking PTPN2 in T cells
WT mice and mice lacking PTPN2 in T cells (PTPN2-CD4Cre mice) were treated with AOM/DSS to induce colorectal tumours. RNA was isolated from tumour and non-tumour tissues in the colon. Colon samples from water-treated WT and PTPN2-CD4Cre mice served as additional control. Total RNA was isolated and t...
ORGANISM(S): Mus musculus 
2020-10-03 | E-MTAB-9629 | biostudies-arrayexpress
GenomicsPTPN2 regulates metabolic flux to affect beta cell susceptibility to inflammatory stress
PTPN2 regulates metabolic flux to affect beta cell susceptibility to inflammatory stress
PRJNA891028 | ENA
GenomicsDeletion of Ptpn2 in B cells contributes to development of autoimmunity
Deletion of Ptpn2 in B cells contributes to development of autoimmunity
PRJNA1254250 | ENA
GenomicsDifferential gene expression in WT mice and mice lacking PTPN2 in T cells
Differential gene expression in WT mice and mice lacking PTPN2 in T cells
PRJEB40613 | ENA
GenomicsEffect of Ptpn2 KO and IFNγ on axon regeneration
Effect of Ptpn2 KO and IFNγ on axon regeneration
PRJNA888974 | ENA
GenomicsLoss-of-function of PTPN2 promotes pathogenic loss of FoxP3+ in RORgt+ Tregs [RNA-seq]
Loss-of-function of PTPN2 promotes pathogenic loss of FoxP3+ in RORgt+ Tregs [RNA-seq]
PRJNA508898 | ENA
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