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ProteomicsA comparative analysis of the interactomes of viral accessory proteins exploiting DDB1 and Cullin Ubiquitin ligases
Viruses have an ambivalent relationship with the host proteome. While several host proteins are indispensable for replication, detrimental restriction factors need to be antagonized. This process is frequently catalysed by viral accessory proteins which exploit the ubiquitin proteasome pathway, DDB1...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-13 | MSV000085095 | MassIVE
TranscriptomicsThe E3 ubiquitin ligase DDB1 controls homeostasis of hematopoietic stem and progenitor cells
Hematopoietic stem cells (HSC) are regulated to keep the balance between self-renewal and differentiation. However, little is known about post-translational regulations in HSCs. In this study, we characterize the role of DDB1, a component of the Cul4A-DDB1 E3 ubiquitin ligase complex, in HSCs and pr...
ORGANISM(S): Mus musculus 
2015-07-10 | E-GEOD-70658 | biostudies-arrayexpress
TranscriptomicsOval cells from DDB1 mutant mouse
Quiescent hepatic stem cells (HSCs) can be activated when hepatocyte proliferation is compromised. Chemical injury rodent models have been widely used to study the locazation, biomarkers, and signaling pathways in HSCs, but these models usually exhibit severe promiscuous toxicity and fail to disting...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-31588 | biostudies-arrayexpress
ProteomicsPulse-SILAC and interactomics reveal distinct DDB1-CUL4 associated factors (DCAFs), cellular functions, and protein substrates
Cullin-RING finger ligases (CRLs) represent the largest family of ubiquitin ligases. They are responsible for the ubiquitination of ~20% of cellular proteins degraded through the proteasome, by catalyzing the transfer of E2-loaded ubiquitin to a substrate. Seven Cullins are described in vertebrates....
ORGANISM(S): Homo sapiens (Human) 
2023-10-11 | PXD042903 | Pride
Pulse-silac Dcafs Ubiquitination Bioid Ddb1 Interactome Cullin4 
ProteomicsDCAF13-COIP-20231218YY0102-DDB1-E2F2
DCAF13-ANTIBODY-HOMO-COIP-20231218YY0102-DDB1-E2F2
ORGANISM(S): Homo Sapiens 
PXD056216 |
GenomicsDDB1 Prepares Brown Adipocytes for Cold-Induced Thermogenesis [ChIP-seq]
DDB1 Prepares Brown Adipocytes for Cold-Induced Thermogenesis [ChIP-seq]
PRJNA791603 | ENA
GenomicsDDB1 Prepares Brown Adipocytes for Cold-Induced Thermogenesis [RNA-seq]
DDB1 Prepares Brown Adipocytes for Cold-Induced Thermogenesis [RNA-seq]
PRJNA791619 | ENA
GenomicsMaternal DDB1 regulates apoptosis and lineage differentiation in porcine preimplantation embryos
Maternal DDB1 regulates apoptosis and lineage differentiation in porcine preimplantation embryos
PRJNA784274 | ENA
ProteomicsA comparative analysis of the interactomes of viral accessory proteins exploiting DDB1 and Cullin Ubiquitin ligases
Viruses have an ambivalent relationship with the host proteome. While several host proteins are indispensable for replication, detrimental restriction factors need to be antagonized. This process is frequently catalysed by viral accessory proteins which exploit the ubiquitin proteasome pathway, DDB1...
ORGANISM(S): Homo sapiens (Human) 
2019-01-14 | PXD007634 | Pride
Proteomics Mass spectrometry Cullin ubiquitin ligases Ddb1 Viral interactome analysis 
GenomicsTranscriptome data of WT and Ddb1-KO activated CD4+ T cells
Transcriptome data of WT and Ddb1-KO activated CD4+ T cells
PRJNA736248 | ENA
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