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Human cytomegalovirus (CMV) is a highly relevant pathogen, and its rodent counterparts serve as common infection models. Global proteome profiling of rat CMV (RCMV)-infected cells uncovered a pronounced loss of the transcription factor STAT2, which is crucial for interferon signalling. Deletion muta...
ORGANISM(S): Cellular Organisms 
Understanding the integrated regulation of cellular processes during viral infection is crucial for developing host-targeted approaches. We have previously reported that an optimal in-vitro infection by influenza A (IAV) requires three components of Cullin 4-RING E3 ubiquitin ligases (CRL4), namely ...
ORGANISM(S): Homo sapiens (Human) Influenza A virus (A/WSN/1933(H1N1)) 
2025-05-06 | PXD050261 | Pride
crosslinking mass spectrometry results for sulfo-SDA crosslinking of human CUL4-NEDD8/ROC1/DDB1/DCAF1-CtD in complex with SAMHD1 and Vpr protein from simian immunodeficiency virus infecting Cercopithecus cephus (SIVmus Vpr)
ORGANISM(S): Homo sapiens (Human) 
2021-07-20 | PXD020453 | Pride
AMBRA1 is a tumor suppressor protein that functions as a substrate receptor of the ubiquitin conjugation system with roles in autophagy and the cell cycle regulatory network. The intrinsic disorder of AMBRA1 has thus far precluded its structural determination. To solve this problem, we analyzed the ...
ORGANISM(S): Homo sapiens (Human) 
2023-11-16 | PXD046056 | Pride
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