Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mature, naive B cells to investigate how the PTPN22 autoimmune susceptibility gene affects the removal of human developing autoreactive B cells.
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene segregates with most autoimmune diseases; its risk allele encodes overactive PTPN22 phosphatases that alter B cell receptor (BCR) signaling potentially involved in the regulation of central B cell tolerance. To assess whether PTPN22 ris...
ORGANISM(S): Homo sapiens 
2010-10-16 | E-GEOD-24736 | biostudies-arrayexpress
GenomicsPTPN22 microbiota
Association of PTPN22 genotype to the murine gut microbiota
PRJEB26758 | ENA
ProteomicsPhosphorylation sites of PTPN22 treated by Calyculin A in 293T cells
Phosphorylation sites of PTPN22 induced by Calyculin A treatment were identified by LC-MS
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD016103 | Pride
Ptpn22 phosphorylation 
ProteomicsImmunoprecipitated PTPN22 Phosphoproteomics from Jurkat Cells
3x FLAG tagged PTPN22 were immunoprecipitated from Jurkat cells stimulated by TCR for 5min, and the proteins were eluted by FLAG peptides. This study aims to explore the phosphorylation sites on PTPN22 phosphatase, identifying two phosphorylation sites Ser325 and Ser449.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-21 | MSV000093717 | MassIVE
ProteomicsThe phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR
The protein tyrosine phosphatases (PTPs) TCPTP, PTPN22, and SHP1 are critical regulators of the activating phophotyrosine (pY) site on the initiating T cell kinase, LckY394, but the broader implications of these phophatases in T cell receptor (TCR) signalling and T cell biology remain unclear. By co...
ORGANISM(S): Homo sapiens (Human) 
2025-08-01 | PXD058624 | Pride
Shp1 Phosphoproteomics Tcptp Ptpn22 T cell signaling 
ProteomicsGlobal phosphoproteomics for CRISPR/Cas9 mediated PTPN22 Ser325 mutagenesis on Jurkat cells
LQF of 3x FLAG PTPN22 WT Jurkat cells compared to S325A and S325E KI mutant Jurkat cells. WT or KI lines were stimulated with or without TCR engagement for 5 min.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-21 | MSV000093718 | MassIVE
GenomicsPTPN22 LOTx dataset
Genotype of PTPN22 SNPs in LOTx donors and recipients
EGAD00010001645 | EGA
ProteomicsRedox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation
PTPN22, a modifier of T cell receptor signaling, and reactive oxygen species are major players in the regulation of chronic autoimmune diseases. As with all protein tyrosine phosphatases the activity of PTPN22 is redox regulated, but if or how such regulation can modulate inflammatory pathways in vi...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-23 | PXD025319 | Pride
Autoimmunity Ptpn22 Reactive oxygen species Lymphocyte signaling 
TranscriptomicsPTPN22 autoimmune susceptibility gene affects the removal of human developing autoreactive B cells
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene segregates with most autoimmune diseases; its risk allele encodes overactive PTPN22 phosphatases that alter B cell receptor (BCR) signaling potentially involved in the regulation of central B cell tolerance. To assess whether PTPN22 risk...
ORGANISM(S): Homo sapiens 
2010-10-16 | GSE24736 | GEO
GenomicsA novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling
A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling
PRJNA1102292 | ENA
Sort   by:  
 Page size