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TranscriptomicsRNAi knockdown of Tip60 and Usp7 in mouse 3T3-L1 adipocytes
Knockdown of Tip60 or Usp7 in differentiated 3T3-L1 adipocytes
ORGANISM(S): Mus musculus 
2013-08-28 | E-TABM-1145 | biostudies-arrayexpress
GenomicsHdac6 regulates Tip60-p400 function in stem cells (sequencing)
The Tip60 (also known as Kat5) lysine acetyltransferase functions broadly as a transcriptional co-activator that acetylates histones. In contrast, Tip60 functions in embryonic stem cells (ESCs) both to silence genes that promote differentiation and to activate genes required for proliferation. The m...
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-42209 | biostudies-arrayexpress
TranscriptomicsRNAi profiling of mouse chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity, experiment A
Proper regulation of chromatin structure is necessary for the maintenance of cell type-specific gene expression patterns. The embryonic stem cell (ESC) expression pattern governs self-renewal and pluripotency. Here, we present an RNAi screen in mouse ESCs of 1008 loci encoding chromatin proteins. We...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-11240 | biostudies-arrayexpress
TranscriptomicsAn RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity
This SuperSeries is composed of the following subset Series: GSE11240: An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity, Experiment A GSE11241: An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Id...
ORGANISM(S): Mus musculus 
2008-07-11 | E-GEOD-11243 | biostudies-arrayexpress
TranscriptomicsHistone acetylation dependent microarray analysis uncovers a role for Tip60 HAT activity in nervous system function and general metabolism
Tip60 is a key histone acetyltransferase (HAT) enzyme that plays a central role in diverse biological processes critical for general cell function, however the chromatin-mediated cell-type specific developmental pathways that are dependent exclusively upon the HAT activity of Tip60 remain to be expl...
ORGANISM(S): Drosophila melanogaster 
2010-11-29 | E-GEOD-25635 | biostudies-arrayexpress
TranscriptomicsAn RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity, Experiment B
Proper regulation of chromatin structure is necessary for the maintenance of cell type-specific gene expression patterns. The embryonic stem cell (ESC) expression pattern governs self-renewal and pluripotency. Here, we present an RNAi screen in mouse ESCs of 1008 loci encoding chromatin proteins. We...
ORGANISM(S): Mus musculus 
2008-07-11 | E-GEOD-11241 | biostudies-arrayexpress
ProteomicsYang_NuA4_TIP60_structural_features
This submission contains the mass spectrometry files for the manuscript by Zhenlin Yang et al. that describes the unique structural features of the NuA4/TIP60 acetyltransferase and chromatin remodeling complex. MS experiments were performed from TAP purified complexes from K562 cells and MS files we...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-11-02 | MSV000093280 | MassIVE
ProteomicsUnique structural features of the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex
The human NuA4/TIP60 co-activator complex, a fusion of the yeast SWR1 and NuA4 complexes, both incorporates the histone variant H2A.Z into nucleosomes and acetylates histones H4/H2A/H2A.Z to play crucial roles regulating gene expression and maintaining genome stability. Our cryo-EM studies show that...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD053207 | Pride
Nua4/tip60 acetyltransferase Ep400 complex Chromatin remodeling complex Ncp 
Proteomics: The Tip60 acetylome is a hallmark of the proliferative state in Drosophila
The acetyltransferase KAT5/Tip60 is a key epigenetic regulator of transcription and the DNA damage response. In Drosophila, Tip60 functions within the DOM-A complex to acetylate histones, but its broader substrate repertoire and cellular roles remain incompletely defined. Here, we comprehensively in...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-07-16 | PXD066107 | Pride
Acetylome Drosophila Tip60 Proliferation 
ProteomicsUnique structural features of the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex
The human NuA4/TIP60 co-activator complex, a fusion of the yeast SWR1 and NuA4 complexes, both incorporates the histone variant H2A.Z into nucleosomes and acetylates histones H4/H2A/H2A.Z to play crucial roles regulating gene expression and maintaining genome stability. Our cryo-EM studies show that...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD053209 | Pride
Nua4/tip60 acetyltransferase P400-ncp complex H2a.z Nua4 and swr1 chromatin modifier and remodeler complexes 
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