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MetabolomicsBlocking NKp46-CCR6-ILC3 autophagy alleviates necrotizing enterocolitis by restoring energy metabolism balance

Group 3 innate lymphoid cells (ILC3s) play a crucial role in intestinal inflammatory disorders such as necrotizing enterocolitis (NEC) in neonates; however, the mechanisms by which ILC3s contribute to NEC remain unclear. In this study, single-cell transcriptomics, in vivo experiments on T cell-de...

2026-04-12 | MTBLS12891 | MetaboLights
TranscriptomicsmiRNA expression profile in CCR6+ regulatory T cells
To detect the miRNA expression profile in CCR6+ regulatory T cells In this study, the total RNA was extracted from CCR6+ regulatory T cells and CCR6- regulatory T cells. Then, the expression profile of miRNA on these cells was detected by microarray.
ORGANISM(S): Mus musculus 
2014-08-05 | E-GEOD-60041 | biostudies-arrayexpress
ProteomicsLL10000 hybridization
The screening of a previously reported fluorescein labelled 10,000 member PNA encoded peptide library allowed information on the interaction between the peptide-ligands and the cell surface receptors to be extracted, identified new peptide ligands for cell surface receptors, and gave crucial informa...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-MEXP-3104 | biostudies-arrayexpress
TranscriptomicsRNA-seq bulk of CCR6+Th-cell subsets in Crohn’s Disease, peripheral blood and intestinal lamina propria
This RNA seq experiment was designed to identify a gene signature of a CCR5-expressing subset of human intestinal Th17-cells. T helper-cells from peripheral blood of healthy donors and from the lamina propria of Crohn’s Disease patients were FACS-purified according to the expression of the chemokine...
ORGANISM(S): Homo sapiens 
2023-07-27 | E-MTAB-13178 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse small intestinal CCR6+ group3 innate lymphoid cells
CCR6+NKp46- ILC3 were isolated from the small intestine of untreated mice by flow cytometry. ILC3 from 3 mice were pooled for subsequent RNA sequencing.
ORGANISM(S): Mus musculus 
2019-10-11 | E-MTAB-8387 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of Tregs from WT mice and Ccr6 KO mice
The experiment was designed to compare transcriptomic differences between WT and Ccr6 KO Tregs during activation. WT and Ccr6 KO Tregs, cells were isolated from mice and cultured in vitro for 3 days with activation using anti-CD3/CD28 beads. Total RNA was extracted using the Trizol method. Quantity ...
ORGANISM(S): Mus musculus 
2024-08-10 | E-MTAB-14288 | biostudies-arrayexpress
ProteomicsCCL20-CCR6 signaling alters the metabolic reprogramming to promote the pathogenic Th17 cell differentiation
Chemokine receptor CCR6 is a G-protein-coupled receptor that binds its high-affinity ligand, CCL20. Among the CD4+ T cells, Th17 and regulatory T cells express CCR6, which facilitates their migration in CCL20-enriched, inflamed tissue. Migration of CCR6+ T cells from secondary lymphoid tissues into ...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-10 | PXD071790 | Pride
Ccr6  th17 cells  ulcerative colitis  chemokine receptor 
TranscriptomicsMolecular mechanisms of HIV-1 permissiveness in CCR4+CCR6+ Th17 cells
We previously reported that CCR4+CCR6+Th17 cells are permissive to HIV, while CXCR3+CCR6- Th1 cells are relatively resistant. To identify molecular mechanisms underlying these differences, we performed a genome-wide transcriptional profiling in CXCR3+CCR6-Th1, CCR4+CCR6-Th2, CCR4+CCR6+Th17, and CXCR...
ORGANISM(S): Homo sapiens 
2015-08-30 | E-GEOD-70396 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human peripheral blood B helper T-cell subsets
Human T-cells that express CXCR5 and/or CCR6 provide help to naive B-cells for IgG production. To understand the molecular pathways that are shared or unique to individual B helper T-cell subsets in human peripheral blood, CD4+IL-7R+CD25-/lo helper T-cells were purified according to the expression o...
ORGANISM(S): Homo sapiens 
2020-03-11 | E-MTAB-8862 | biostudies-arrayexpress
ProteomicsCell array 10000 hybridization
The incubation of a 10,000 member PNA-encoded peptide library with cells over-expressing the alpha(v)beta(3) and alpha(v)beta(5) integrins (D54) or CCR6 (HEK293T-CCR6) followed by microarray analysis allowed detailed information on the interaction between peptide-ligands and cell surface receptors t...
ORGANISM(S): Homo sapiens 
2011-08-10 | E-MEXP-3103 | biostudies-arrayexpress
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