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Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells have been proposed as mediators between lipid overload and insulin resistance, but recent studies found decreased i...
ORGANISM(S): Mus musculus 
Identification of SortaseA cleavable MHC class I proteins (CD1d, H2Kb) for shotgun lipidomics
ORGANISM(S): Mus musculus (Mouse) 
2022-07-08 | PXD034366 | Pride
Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear. Here we show, using chimeric mice, cell depletion and adoptive cell transfer...
ORGANISM(S): Mus musculus 
The ability to detect and isolate bGL1-22/LGL1–specific human type II NKT cells allowed us to compare the global gene expression profiles of these cells with type I NKT cells using microarray analysis. Principal component analysis revealed that the gene expression profile signature for bGL1-22 and...
ORGANISM(S): Homo sapiens 
CD1d expression by thymocytes is required to select iNKT cells. When CD1d is expressed only on thymocytes (pLck-CD1d tg mice), iNKT cells are hyperresponsive to antigen stimulation suggesting that, in physiological conditions, these cells undergo functional education mediated by additional CD1d-expr...
ORGANISM(S): Mus musculus 
Microarray analysis was performed to determine the transcriptional profiles of NKT, CD1d-aGC+ Va24-, and CD4 T cells. Clones of NKT, CD1d-aGC+ Va24-, and CD4 T cells were generated using peripheral blood drawn from two healthy individuals. RNA was extracted from cells that had been either rested (1...
ORGANISM(S): Homo sapiens 
RNA-seq of skin tissues from WT and Cd1d KO B6 mice
CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells
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