Sort   by:  
 Page size 
TranscriptomicsT-cell co-stimulation
Optimal activation of T cells requires effective occupancy of both the antigen-specific T cell receptor and a second coreceptor such as CD28. We used cDNA microarrays to characterize the genomic expression program in human peripheral T cells responding to stimulation of these receptors. We found tha...
ORGANISM(S): Homo sapiens 
2005-11-18 | E-GEOD-3630 | biostudies-arrayexpress
GenomicsProfiling of Naïve (CD45RA+CD28+), EM (CD45RA-CD28-) and TEMRA (CD45RA+CD28-) CD8+ T cells
Profiling of Naïve (CD45RA+CD28+), EM (CD45RA-CD28-) and TEMRA (CD45RA+CD28-) CD8+ T cells
PRJNA530997 | ENA
TranscriptomicsTranscription profiling of human peripheral T cells responding to stimulation of antigen-specific T cell receptor and CD28
Optimal activation of T cells requires effective occupancy of both the antigen-specific T cell receptor and a second coreceptor such as CD28. We used cDNA microarrays to characterize the genomic expression program in human peripheral T cells responding to stimulation of these receptors. We found tha...
ORGANISM(S): Homo sapiens 
2005-09-23 | E-SMDB-748 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of CD8 T cell subsets from healthy young and elderly persons
We isolated highly purified CD8+CD28+ and CD8+CD28- T cell populations from healthy young and elderly persons for gene expression profiling using Affymetrix oligonucleotide microarrays. We demonstrate that the gene expression profile of CD8+CD28- T cells is very similar in young and elderly persons....
ORGANISM(S): Homo sapiens 
2010-09-03 | E-MEXP-2345 | biostudies-arrayexpress
GenomicsProfiling of Naïve (CD45RA+CD28+), EM (CD45RA-CD28-) and TEMRA (CD45RA+CD28-) CD8+ T cells from kidney transplanted patients
Profiling of Naïve (CD45RA+CD28+), EM (CD45RA-CD28-) and TEMRA (CD45RA+CD28-) CD8+ T cells from kidney transplanted patients
PRJNA814511 | ENA
GenomicsCD28 region-capture HiC of resting and anti-CD3/CD28-stimuated Jurkat cells
CD28 region-capture HiC of resting and anti-CD3/CD28-stimuated Jurkat cells
PRJNA1162471 | ENA
TranscriptomicsProfiling of Jurkat T cells activated with CD3, CD28 and PMA at 1 and 8 hours
T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into the Th1, Th2, Th17 or iTreg phenotype, depending on environmental co-stimulatory signals. In order to identify the genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes ...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-30676 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of chimeric CD4+CD28null and CD4+CD28+ T-cells in humanized mice.
The major goal of this experiment was to identify the overall changes in gene expression of human CD4+CD28 null T-cells that develop after repetitive [xeno] antigen stimulation, in comparison to normal CD4+CD28+ T-cells. These cells were derived by adoptive transfer of human CD4 T-cells from a norm...
ORGANISM(S): Homo sapiens 
2015-01-05 | E-GEOD-28484 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of healthy human CD4+ cells after CD3 and CD28 stimulation
Genome-wide DNA methylation reference profiles of CD4+ cells after CD3 and CD28 stimulation in two healthy human individuals using the MeDIP technique a custom oligonucleotide array targetting the vast majority of annotated TSSs and non-promoter CGIs in the human genome.
ORGANISM(S): Homo sapiens 
2010-03-23 | E-MTAB-207 | biostudies-arrayexpress
ProteomicsInteractomics of the RLTPR protein explain its essential role for costimulation via CD28
The RLTPR cytosolic protein has an essential role in CD28 costimulation but its mode of action and importance in human T cells remain elusive. Here, using mass spectrometry we showed that CD28, RLTPR and the CARMA1 cytosolic adaptor physically associate in mouse T cells. Although RLTPR is thought to...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-27 | PXD003870 | Pride
Mouse Rltpr Lc-ms/ms 
Sort   by:  
 Page size