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ProteomicsInteractomics of the RLTPR protein explain its essential role for costimulation via CD28
The RLTPR cytosolic protein has an essential role in CD28 costimulation but its mode of action and importance in human T cells remain elusive. Here, using mass spectrometry we showed that CD28, RLTPR and the CARMA1 cytosolic adaptor physically associate in mouse T cells. Although RLTPR is thought to...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-27 | PXD003870 | Pride
Mouse Rltpr Lc-ms/ms 
UnknownGenomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E).
Not available
S-EPMC5609333 | biostudies-literature
UnknownThe scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.
Not available
S-EPMC5068240 | biostudies-literature
UnknownDual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations.
Not available
S-EPMC5068239 | biostudies-literature
ProteomicsAnalysis of the interactome of the RLTPR/CARMIL2 protein in CD4+ T cells
We analyzed the interactome of the mouse protein RLTPR (CARMIL2) using an affinity purification method based on the introduction of a One-Strep-tag (OST) sequence in the C-terminus of the bait protein by genetic engineering of primary mouse T cells. We used mouse models expressing the tagged version...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-12 | PXD055893 | Pride
Ap-ms Primary t cell Rltpr Interactome Ost tag Carmil2 
UnknownA potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction.
Not available
S-EPMC5118205 | biostudies-literature
TranscriptomicsDual T cell– and B cell–intrinsic deficiency in humans [CD4+ T cell SubSeries]
Human RLTPR deficiency is a combined immunodeficiency affecting the CD28-responsive pathway in T cells and the BCR-responsive pathway in B cells. This SubSeries contains high throughput gene expression data from primary CD4+ T cells of patients with RLTPR deficiency and controls.
ORGANISM(S): Homo sapiens 
2022-11-07 | GSE169506 | GEO
TranscriptomicsGenotyping data for seven patients from three unrelated, consanguineous multiplex families that presented with combined immunodeficiency, and were found to harbour mutations in CARMIL2
Combined immunodeficiencies are a heterogeneous collection of primary immune disorders that exhibit defects in T cell development or function, along with impaired B cell activity even in light of normal B cell maturation. CARMIL2 (RLTPR) is a protein involved in cytoskeletal organization and cell mi...
ORGANISM(S): Homo sapiens 
2018-01-25 | E-MTAB-6440 | biostudies-arrayexpress
GenomicsDual T cell– and B cell–intrinsic deficiency in humans [CD4+ T cell SubSeries]
Dual T cell– and B cell–intrinsic deficiency in humans [CD4+ T cell SubSeries]
PRJNA717109 | ENA
UnknownA Novel Pathogenic Variant in CARMIL2 (RLTPR) Causing CARMIL2 Deficiency and EBV-Associated Smooth Muscle Tumors.
Not available
S-EPMC7314954 | biostudies-literature
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