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GenomicsEpigenetic profiling in CD4 and CD8 T cells from Gravesâ?? disease patients reveals changes in genes associated with T cell receptor signaling [ChIP-seq]
In Gravesâ?? disease (GD), a combination of genetic, epigenetic and environmental factors causes an autoimmune response to the thyroid gland, characterized by lymphocytic infiltrations and autoantibodies targeting the thyroid stimulating hormone receptor (TSHR) and other thyroid antigens. To identif...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-GEOD-71952 | biostudies-arrayexpress
TranscriptomicsEpigenetic profiling in CD4 and CD8 T cells from Graves’ disease patients reveals changes in genes associated with T cell receptor signaling [methylation]
In Graves’ disease (GD), a combination of genetic, epigenetic and environmental factors causes an autoimmune response to the thyroid gland, characterized by lymphocytic infiltrations and autoantibodies targeting the thyroid stimulating hormone receptor (TSHR) and other thyroid antigens. To identif...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-GEOD-71955 | biostudies-arrayexpress
MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
TranscriptomicsMolecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation
CD8+ T cells play a critical role in the immune response to viral pathogens. Persistent human CMV (HCMV) infection results in a strong increase in the number of virus-specific, quiescent effector-type CD8+ T cells with constitutive cytolytic activity, but the molecular pathways involved in the ind...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-24151 | biostudies-arrayexpress
TranscriptomicsEpigenetic profiling in CD4 and CD8 T cells from Graves’ disease patients reveals changes in genes associated with T cell receptor signaling [gene expression]
In Graves’ disease (GD), a combination of genetic, epigenetic and environmental factors causes an autoimmune response to the thyroid gland, characterized by lymphocytic infiltrations and autoantibodies targeting the thyroid stimulating hormone receptor (TSHR) and other thyroid antigens. To identif...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-GEOD-71956 | biostudies-arrayexpress
TranscriptomicsDynamics of Virus-specific CD8+ T cells in the Human Nasal Cavity
The goal of this experiment is to compare the transcriptomic profile of CD8+ T cells isolated from the nasal cavity and whole blood at two different state, baseline and CD3/28 activated. This will allow us to characterise the unique features of CD8+ T cells in the nasal cavity. We isolated CD8+CD4...
ORGANISM(S): Homo sapiens 
2025-08-23 | E-MTAB-15436 | biostudies-arrayexpress
TranscriptomicsEarly specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene expression analyses
T lymphocytes responding to microbial infection give rise to effector cells that mediate acute host defense and memory cells that provide long-lived immunity, but the fundamental question of when and how these cells arise remains unresolved. Here we combine single-cell gene expression analyses with...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54321 | biostudies-arrayexpress
GenomicsGlobal DNA Methylation Remodeling Accompanies CD8 T Cell Effector Function
In response to acute infection CD8 T cells differentiate into effector cells capable of clearing the antigen. While the transcriptional and functional changes have previously been studied little is known of the epigenetic modifications that accompany this differentiation process. To gain insights ...
ORGANISM(S): Mus musculus 
2013-08-18 | E-GEOD-44638 | biostudies-arrayexpress
TranscriptomicsCMV infection induces a rapid and sustained change in the expression of Natural Killer Cell Receptors on CD8+ T Cells
The CD8+ T cell compartment of human cytomegalovirus (CMV) seropositive individuals characteristically contains a high proportion of cells that expresses Natural Killer Cell Receptors (NKR) which may contribute to the surveillance of virus-infected cells. To test if this enhanced expression is a dir...
ORGANISM(S): Homo sapiens 
2008-08-28 | E-GEOD-12589 | biostudies-arrayexpress
TranscriptomicsFoxO1 Controls Effector to Memory Transition and Maintenance of Functional CD8 T-Cell Memory
During a T cell response, naïve CD8 T cells differentiate into effector cells. Subsequently, a subset of effector cells termed memory precursor effector cells (MPECs) further differentiates into functionally mature memory CD8 T cells. The transcriptional network underlying this carefully scripted p...
ORGANISM(S): Mus musculus 
2013-06-25 | E-GEOD-45673 | biostudies-arrayexpress
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