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MetabolomicsMetabolite assay of T cells that are antigen-specially activated by viscoelastic synthetic antigen presenting cells

Adoptive T cell receptor (TCR)–based immunotherapy offers a powerful strategy to target solid tumors. However, the physical properties of the antigen-presenting interface regulate T cell metabolic programming remains poorly defined. Here we develop synthetic viscoelastic activating cells (SynVAC)...

2026-09-03 | MTBLS15444 | MetaboLights
MetabolomicsComparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. and characteristic pure compounds reveals differential anti-inflammatory effects on human T cells

Introduction

Chronic inflammation is a hallmark of chronic wounds and inflammatory skin diseases. Due to a hyperactive and prolonged inflammation triggered by proinflammatory immune cells, transitioning to the repair and healing phase is halted. T cells may exacerbate the proinflammatory mil...
2025-07-09 | MTBLS9800 | MetaboLights
TranscriptomicsDynamics of Virus-specific CD8+ T cells in the Human Nasal Cavity
The goal of this experiment is to compare the transcriptomic profile of CD8+ T cells isolated from the nasal cavity and whole blood at two different state, baseline and CD3/28 activated. This will allow us to characterise the unique features of CD8+ T cells in the nasal cavity. We isolated CD8+CD4...
ORGANISM(S): Homo sapiens 
2025-08-23 | E-MTAB-15436 | biostudies-arrayexpress
TranscriptomicsDistinguishing innate memory CD8+ T from homeostatically expanded CD8+ T cells
Innate memory phenotype (IMP) CD8+ T cells are non-conventional αβ T cells exhibiting features of innate immune cells, and are significantly increased in the absence of non-receptor tyrosine kinase ITK. Their developmental path and function are not clear, particularly whether they can contribute to ...
ORGANISM(S): Mus musculus 
2013-02-19 | E-GEOD-41482 | biostudies-arrayexpress
TranscriptomicsMurine CD8+ T cells: in vitro-derived vs. thymocytes
Transcriptional profiling of mouse in-vitro derived CD8+ cells (obtained after culturing BM-HSCs isolated from B6 mice) with OP9-DL1 cells for 35 days were compared to CD8+ thymocytes isolated from 4-5 weeks old B6 mice. Our goal was to determine similarities and differences in gene expression prof...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-37669 | biostudies-arrayexpress
TranscriptomicsExpression data from WT and TCF-1-deficient memory CD8 T cells
TCF-1 is an HMG family transcription factor which is known to be activated by the canonical Wnt signaling pathway and modulated by other signals such as those derived from T cell receptor. We found that during CD8 T cell responses, TCF-1 deficiency impaired long-term maintenance of antigen-specific ...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-20754 | biostudies-arrayexpress
TranscriptomicsCMV infection induces a rapid and sustained change in the expression of Natural Killer Cell Receptors on CD8+ T Cells
The CD8+ T cell compartment of human cytomegalovirus (CMV) seropositive individuals characteristically contains a high proportion of cells that expresses Natural Killer Cell Receptors (NKR) which may contribute to the surveillance of virus-infected cells. To test if this enhanced expression is a dir...
ORGANISM(S): Homo sapiens 
2008-08-28 | E-GEOD-12589 | biostudies-arrayexpress
TranscriptomicsCD8+ T cells: IL-10+ VS IL-10-
Transcriptional profiling and gene expression profiling analysis of sorted CD8+IL-10+ T cells compared to CD8+IL-10- T cells using IL-10-GFP(tiger) reporter mice Two sample, CD8+IL-10+ T cells vs CD8+IL-10- T cells. Three replicate per array.
ORGANISM(S): Mus musculus 
2013-06-21 | E-GEOD-37739 | biostudies-arrayexpress
TranscriptomicsGene expression profile of murine tolerant, self-antigen specific CD8 T cells
Genomewide microarray analysis of murine tolerant, self-antigen specific CD8 T cells to identify genes and pathways underlying peripheral T cell tolerance Gene signature of tolerant CD8 T cells was compared to the signatures of naïve T cells, memory T cells, rescued T cells (=tolerant T cells underg...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-32025 | biostudies-arrayexpress
TranscriptomicsGene expression in Galectin-3 KO vs. WT CD8 T cells
The goal of this study was to examine differences in gene expression of tumor specific CD8 T cells in an in vivo tumor mouse model after inhibition of galectin-3 protein expression by genetic knockout. Galectin-3 is thought to modulate CD8 T cell response by cross-linking cell surface glycoproteins...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-59454 | biostudies-arrayexpress
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