Sort   by:  
 Page size 
MetabolomicsCaffeine Enhances Antitumor T-cell Activity via COL12A1/IDO1/Kyn axis and Sensitivity to Anti-PD-1 Immunotherapy in Colorectal Cancer
Metabolomic sequencing on supernatants from caffeine-treated and untreated tumor cells to identify which metabolites are involved in activating CD8+ T cells
2025-05-06 | MTBLS11623 | MetaboLights
MetabolomicsFuzheng Jiedu Xiaoji Formula Enhances Anti-PD-1 Therapy for Hepatocellular Carcinoma by Inhibiting Regulatory T Cell Lipotoxicity

Background: The objective response rate of anti-programmed death receptor 1 (PD-1) immunotherapy in hepatocellular carcinoma (HCC) remains limited. The tumor immunosuppressive microenvironment mediated by regulatory T cells (Tregs) is a key bottleneck. The traditional Chinese medicine (TCM) compo...

2025-12-05 | MTBLS13458 | MetaboLights
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
TranscriptomicsTranscriptome differences in HCC infiltrated CD8+ T cells in effector and exhaustion state
CD8+ T cells isolated from HCC tissue were divided into three groups: PD1-TIM3- CD8+ TILs, exhibiting full effector function; PD1-intTIM3+ CD8+ TILs, exhibiting partial exhaustion; and PD1-hiTIM3+ CD8+ TILs, exhibiting severe exhaustion, as reflected by the differences in their ability to produce ef...
ORGANISM(S): Homo sapiens 
2019-12-31 | E-MTAB-7278 | biostudies-arrayexpress
TranscriptomicsSingle-cell characterization of anti-LAG3+anti-PD1 treatment in melanoma patients
We evaluated blood samples from 6 patients with metastatic melanoma treated with anti-LAG3+anti-PD1 (160+480 mg) in a phase I trial (NCT01968109) using single-cell RNA and T cell receptor (TCR) sequencing (scRNA+TCRαβ-seq, 10X 5') combined with other multiomics profiling (flow, cytokine, TCRb-seq) f...
ORGANISM(S): Homo sapiens 
2023-02-03 | E-MTAB-12733 | biostudies-arrayexpress
GenomicsGene expression profiles of PD1-high, PD1-intermediate, and PD1-negative tumor-infiltrating CD8 T cells in hepatocellular carcinoma
Gene expression profiles of PD1-high, PD1-intermediate, and PD1-negative tumor-infiltrating CD8 T cells in hepatocellular carcinoma
PRJNA436904 | ENA
TranscriptomicsComparison of gene expression profiles of HIV-specific CD8 T cells from controllers and progressors and Jurkat cells with or without PD-1 ligation
This SuperSeries is composed of the following subset Series: GSE24026: Comparison of gene expression profiles of Jurkat cells with or without PD-1 ligation GSE24081: Comparison of gene expression profiles of HIV-specific CD8 T cells from controllers and progressors Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-10-03 | E-GEOD-24082 | biostudies-arrayexpress
ProteomicsHigh-dose ascorbic acid synergizes with anti-PD1 therapy in non-small cell lung cancer in vitro and in vivo models
Introduction: Immune checkpoint inhibitors(ICIs) targeting programmed cell death protein 1 (PD1) confer significant survival benefits to patients with non-small cell lung cancer (NSCLC). However, there remains a substantial unmet need to identify therapeutic approaches to overcome resistance and pr...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-15 | PXD059688 | Pride
Lc-msms Mouse Lung cancer 
GenomicsSMART-seq of PD1+ and PD1- CD8 T cells derived from Setx L389S (Setx KI) mice
SMART-seq of PD1+ and PD1- CD8 T cells derived from Setx L389S (Setx KI) mice
PRJNA821103 | ENA
GenomicsCD8+ PD1+ T-cells drive liver cancer in NASH
PD-1-targeted immunotherapy in non-alcoholic steatohepatitis-induced liver cancer induces a pro-tumorigenic environment through CD8+ PD1+ T-cells.​​
PRJEB36747 | ENA
Sort   by:  
 Page size