Sort   by:  
 Page size 
TranscriptomicsCDK6 as key regulator of hematopoietic and leukemic stem cell activation.
The cyclin-dependent kinases (CDK) CDK6 and CDK4 have redundant functions in regulating cell-cycle progression. We describe a novel role for CDK6 in hematopoietic and leukemic stem cells (HSCs and LSCs) that exceeds its function as cell-cycle regulator. Although hematopoiesis appears regular under s...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-62012 | biostudies-arrayexpress
ProteomicsDistinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders
CDK4/6 inhibitors (CDK4/6i) are effective in metastatic breast cancer, but they have been only modestly effective in most other tumor types. Here we show that tumors expressing low CDK6 rely on CDK4 function, and are exquisitely sensitive to CDK4/6i. In contrast, tumor cells expressing both CDK4 and...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023137 | Pride
Cdk4/6 inhibitors and degraders Cdk6 complex Tumor 
GenomicsCDK6 antagonizes p53-induced responses during tumorigenesis
CDK6 antagonizes p53-induced responses during tumorigenesis
PRJNA453920 | ENA
GenomicsChIP sequencing experiment of HA-tagged WT CDK6 or of a C-terminally truncated variant of CDK6 (CDK6 delta-C) in BCR-ABL1 expressing cell lines
The cell cycle kinase CDK6 interacts with a variety of proteins including cyclins and members of the INK4 and Cip/Kip families. These interactions are thought to involve primarily the N-lobe of the protein. Less is known about the role of the C-lobe for the function of CDK6. In this experiment we as...
ORGANISM(S): Mus musculus 
2024-06-30 | E-MTAB-13798 | biostudies-arrayexpress
TranscriptomicsCDK6 antagonizes p53-induced responses during tumorigenesis
CDK6 induces a complex transcriptional program to block p53 in hematopoietic cells. CDK6 binds to the promoters of genes including p53-antagonists. Cells lacking CDK6 kinase function are required to mutate p53 to achieve a fully transformed immortalized state.
ORGANISM(S): Mus musculus 
2018-08-06 | GSE113752 | GEO
TranscriptomicsRNA-Seq of murine megakaryocyte progenitors (MkPs) from Cdk6 knockout and Cdk6 wild-type CALR-mutant mice
This experiment was performed to elucidate the effects of CDK6 on CALR-mutant Myeloproliferative Neoplasms. VavCre CALRdel52 knockin mice were crossed with full-body Cdk6-/- mice to obtain Cdk6-/- CALRdel52 mice. Bone marrow from mice of the four genotypes Cdk6+/+ CALR+/+ (wild-type), Cdk6+/+ CALRde...
ORGANISM(S): Mus musculus 
2026-08-03 | E-MTAB-15404 | biostudies-arrayexpress
TranscriptomicsA cutting-edge approach unravels a novel role for CDK6 in leukemic progenitor cells
CDK6 induces a complex transcriptional program to block p53 in hematopoietic cells. CDK6 binds to the promoters of genes including p53-antagonists. Cells lacking CDK6 kinase function are required to mutate p53 to achieve a fully transformed immortalized state.
ORGANISM(S): Mus musculus 
2021-01-22 | GSE154464 | GEO
Unknownp27 inhibits CDK6/CCND1 complex formation resulting in cell cycle arrest and inhibition of cell proliferation.
Not available
S-EPMC6237435 | biostudies-literature
TranscriptomicsTranscription profiling of mouse non-transformed cell (NIH3T3 + vector) and a transformed cell (NIH3T3 + Fbxo7).
The aim of this experiment was to get a comparison of the signatures between a non-transformed cell (NIH3T3 + vector) and a transformed cell (NIH3T3 + Fbxo7). NIH3T3 cells become transformed after the stable integration of the Fbxo7 gene. Fbxo7 potentiates cyclin D/cdk6 activity.
ORGANISM(S): Mus musculus 
2005-09-30 | E-MEXP-369 | biostudies-arrayexpress
TranscriptomicsGene expression changes associated with kinase-inactivated Cdk6 or a complete Cdk6 KO in mouse HSC/MPP1 cells after two rounds of transplantation
A kinase-inactivated variant of Cdk6 (Cdk6_K43M) was associated with prolonged repopulation potential of mouse lineage-negative, Sca1-positive, cKit-positive, CD150-positive, CD48-negative (HSC/MPP1) cells. In order to understand differences between Cdk6_K43M HSC/MPP1 cells, and HSC/MPP1 cells carry...
ORGANISM(S): Mus musculus 
2024-05-22 | E-MTAB-13145 | biostudies-arrayexpress
Sort   by:  
 Page size