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TranscriptomicsMolecular rules governing de novo methylation in cancer
De novo methylation of CpG islands is seen in many tumors, but the general rules governing this process are not known. By analyzing DNA from tumors, as well as normal tissues, and by utilizing a wide range of published data, we have been able to identify a well-defined set of tumor targets, each of...
ORGANISM(S): Homo sapiens 
2014-03-26 | E-GEOD-38142 | biostudies-arrayexpress
UnknownB cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5.
Not available
S-EPMC1635547 | biostudies-literature
UnknownLocalized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions.
Not available
S-EPMC3685187 | biostudies-literature
UnknownAnalysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus.
Not available
S-EPMC122807 | biostudies-literature
TranscriptomicsDetection of aberrant DNA methylation in undifferentiated and differentiated human ES cells compared to normal fetal tissues
Embryonic stem cells can be differentiated in vitro to produce a variety of somatic cell types. We have employed the mDIP method combined with hybridization to a tiling microarray to obtain a genome-wide methylation analysis of all UnMethylated Regions(UMRs). We show that this differentiation is ac...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-24270 | biostudies-arrayexpress
TranscriptomicsCpG island-specific demethylation pathway in ES cells
Following erasure in the early animal embryo, a new bimodal DNA methylation pattern is regenerated at the time of implantation in each individual through a wave of generalized de novo modification with CpG islands specifically left unmethylated. In this paper, we ask whether CpG islands are M-bM-^@M...
ORGANISM(S): Mus musculus 
2013-11-17 | E-GEOD-48923 | biostudies-arrayexpress
TranscriptomicsDetection of aberrant DNA methylation in undifferentiated and differentiated mouse ES cells compared to normal tissues
Embryonic stem cells can be differentiated in vitro to produce a variety of somatic cell types. We have employed the mDIP method combined with hybridization to a CpG islend microarray . We show that this differentiation is accompanied by an intrinsic process of extensive aberrant CpG island de novo ...
ORGANISM(S): Mus musculus 
2014-02-05 | E-GEOD-54664 | biostudies-arrayexpress
UnknownThe structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes.
Not available
S-EPMC2465810 | biostudies-literature
UnknownIdentification of core DNA elements that target somatic hypermutation.
Not available
S-EPMC3664039 | biostudies-literature
UnknownCoronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.
Not available
S-EPMC9020988 | biostudies-literature
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