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TranscriptomicsConserved functional antagonism between CELF and MBNL proteins regulates stem cell-specific alternative splicing and regeneration in planarians
Understanding gene regulation in stem cells is key to understanding stem cell biology. Contrary to transcriptional regulation the function of alternative splicing (AS) in stem cells is poorly understood. Here we study function and mechanisms of AS in a powerful in vivo model for stem cell biology, t...
ORGANISM(S): Schmidtea mediterranea 
2016-08-01 | E-GEOD-75594 | biostudies-arrayexpress
TranscriptomicsConserved functional antagonism between CELF and MBNL proteins regulates stem cell-specific alternative splicing and regeneration in planarians
Understanding gene regulation in stem cells is key to understanding stem cell biology.Contrary to transcriptional regulation the function of alternative splicing (AS) in stem cells is poorly understood. Here we study function and mechanisms of AS in a powerful in vivo model for stem cell biology, th...
ORGANISM(S): Schmidtea mediterranea 
2016-08-01 | E-GEOD-75296 | biostudies-arrayexpress
UnknownThe role of CELF proteins in neurological disorders.
Not available
S-EPMC3062235 | biostudies-literature
TranscriptomicsGene expression analysis in mice with heart muscle-specific repression of CELF activity (MHC-CELFdelta)
Members of the CUG-BP, Elav-like family (CELF) regulate alternative splicing in the heart. In MHC-CELFdelta transgenic mice, CELF splicing activity is inhibited postnatally in heart muscle via expression of a nuclear dominant negative CELF protein under an a-myosin heavy chain promoter. MHC-CELFde...
ORGANISM(S): Mus musculus 
2013-08-26 | E-GEOD-40677 | biostudies-arrayexpress
UnknownCardiac tissue-specific repression of CELF activity disrupts alternative splicing and causes cardiomyopathy.
Not available
S-EPMC1168813 | biostudies-literature
TranscriptomicsAnalysis of cardiac gene expression in juvenile versus mature mice with repressed CELF activity (MHC-CELFdelta)
CUG-BP, Elav-like family (CELF) proteins regulate alternative splicing. In MHC-CELFdelta transgenic mice, CELF-mediated alternative splicing is disrupted in heart muscle via expression of a nuclear dominant negative CELF protein under an alpha-myosin heavy chain promoter. MHC-CELFdelta mice develo...
ORGANISM(S): Mus musculus 
2014-10-16 | E-GEOD-62363 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in mice with heart muscle-specific repression of CELF activity (MHC-CELFdelta)
Members of the CUG-BP, Elav-like family (CELF) regulate alternative splicing in the heart. In MHC-CELFdelta transgenic mice, CELF splicing activity is inhibited postnatally in heart muscle via expression of a nuclear dominant negative CELF protein under an a-myosin heavy chain promoter. MHC-CELFdelt...
ORGANISM(S): Mus musculus 
2013-08-26 | GSE40677 | GEO
UnknownCELF Family Proteins in Cancer: Highlights on the RNA-Binding Protein/Noncoding RNA Regulatory Axis.
Not available
S-EPMC8537729 | biostudies-literature
UnknownCellobiose-6-phosphate hydrolase (CelF) of Escherichia coli: characterization and assignment to the unusual family 4 of glycosylhydrolases.
Not available
S-EPMC103698 | biostudies-literature
UnknownSuppression of miR-106a-5p expression inhibits tumorigenesis via increasing CELF-2 expression in spinal cord glioma.
Not available
S-EPMC8258617 | biostudies-literature
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