Sort   by:  
 Page size 
MetabolomicsEndoplasmic reticulum-derived bodies enable a single-cell chemical defense in Brassicaceae plants
Brassicaceae plants have a dual-cell type of chemical defense against herbivory. Here we show a novel single-cell defense involving endoplasmic reticulum (ER)-derived organelles (ER bodies) and the vacuoles. We identify various glucosinolates as endogenous substrates of the ER-body β-glucosidases BG...
2020-02-04 | MTBLS1383 | MetaboLights
MetabolomicsNormalization strategies for lipidome data in cell line panels & Distinct lipidomic profiles in breast cancer cell lines relate to proliferation and EMT phenotypes

Sample collection can significantly affect measurements of relative lipid concentrations in cell line panels, hiding intrinsic biological properties of interest between cell lines. Most quality control steps in lipidomic data analysis focus on controlling technical variation. Correcting for the t...

2025-08-07 | MTBLS9493 | MetaboLights
MetabolomicsStable Isotope-Assisted Metabolomics for Deciphering Xenobiotic Metabolism in Mammalian Cell Culture
Xenobiotics are ubiquitous in the environment and modified abundantly in the human body by phase I and II metabolism. Liquid chromatography coupled to high resolution mass spectrometry is a powerful tool to investigate these biotransformation products. Here, we present a workflow based on stable iso...
2020-04-14 | MTBLS1358 | MetaboLights
TranscriptomicsShort-term (12h) ATRA treatment of embryoid bodies.
We used microarrays to detail the global programme of gene expression in embryonic stem cells, early differentiated embrioid bodies and effect of short-term ATRA treatment. Expression data from undifferentiated mouse embryonic stem cells (D3), four-day old aggregated embrioid bodies and 12h atRA or ...
ORGANISM(S): Mus musculus 
2010-07-16 | E-GEOD-20919 | biostudies-arrayexpress
MetabolomicsA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
MetabolomicsLipidomic analysis of Toxoplasma gondii extracellular vesicles across host cell types

Introduction. Toxoplasma gondii is an obligate intracellular parasite with an exceptional capacity to colonize a broad range of host species and cell types. Successful infection depends on its ability to manipulate host metabolism, including lipid pathways that are essential for membrane biogenes...

2026-02-11 | MTBLS13253 | MetaboLights
MetabolomicsMulti-omics Analysis of ACAD11-mediated Lipid Metabolic Reprogramming in the Prognosis of Clear Cell Renal Cell
Clear cell renal cell carcinoma (ccRCC) is pathologically characterized by profound intracellular lipid droplet accumulation. To explore the dysregulated lipid metabolic network and identify crucial drivers, an integrated transcriptomic and untargeted metabolomic analysis was conducted. In this stud...
2026-08-31 | MTBLS15414 | MetaboLights
ProteomicsProteomic analysis of koala (Phascolarctos cinereus) spermatozoa and prostatic bodies
The aims of this study were to investigate the proteome of koala (Phascolarctos cinereus) spermatozoa and that of the prostatic bodies with which they form intimate contact at the moment of ejaculation. For this purpose, spermatozoa and prostatic bodies were obtained from four adult male koala by el...
ORGANISM(S): Phascolarctos cinereus (Koala) 
2021-08-23 | PXD024250 | Pride
Spermatozoa Koala Prostatic bodies Proteomics 
ProteomicsProteome Profiling of PBMC-originated, iPSC-derived Lentoid Bodies at differentiation day 35
Differentiation of pluripotent stem cells into lentoid bodies is important for the understanding of the lens development and investigating the processes critical for lens morphogenesis. This Study was initiated to investigate a comprehensive proteome profiling of the peripheral blood mononuclear cel...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD009633 | Pride
Mass-spectrometry Ipsc-derived lentoid bodies Proteome Pbmc 
TranscriptomicsTranscription profiling of mouse pseudopodia AND cell bodies IN response TO LPA stimulation OR fibronectin
This SuperSeries is composed of the following subset Series:; GSE10226: Analysis of RNA distribution between pseudopodia and cell bodies in response to LPA stimulation; GSE10227: Analysis of RNA distribution between pseudopodia and cell bodies in response to Fibronectin Experiment Overall Design: Re...
ORGANISM(S): Mus musculus 
2008-04-05 | E-GEOD-10230 | biostudies-arrayexpress
Sort   by:  
 Page size