Sort   by:  
 Page size 
MetabolomicsMetabolomic Sequencing of Cell-Free Supernatant from Bacillus strain 541

The 4-6 minute fraction from the HPLC fractionation of the bacterial culture supernatant of porcine-derived probiotic Bacillus strain 541.

2025-09-08 | MTBLS12956 | MetaboLights
MetabolomicsMetabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei
In vitro culture methods underpin many experimental approaches to biology and drug discovery. The modification of established cell culture methods to be more biologically relevant, or to optimise growth, is traditionally a laborious task. Emerging metabolomics technology enables rapid evaluation of ...
2015-05-14 | MTBLS49 | MetaboLights
MetabolomicsStable Isotope-Assisted Metabolomics for Deciphering Xenobiotic Metabolism in Mammalian Cell Culture
Xenobiotics are ubiquitous in the environment and modified abundantly in the human body by phase I and II metabolism. Liquid chromatography coupled to high resolution mass spectrometry is a powerful tool to investigate these biotransformation products. Here, we present a workflow based on stable iso...
2020-04-14 | MTBLS1358 | MetaboLights
MetabolomicsLimited oxygen availability in standard cell culture alters metabolism and function in terminally differentiated cells

Cell culture is generally considered to be hyperoxic. However, the importance of cellular oxygen consumption is often underappreciated, with rates of oxygen consumption often sufficient to cause hypoxia at cell monolayers. We initially focused on cultured adipocytes as a terminally differentiated...

2024-02-21 | MTBLS6677 | MetaboLights
MetabolomicsLactobacillus rhamnosus GG (LGG) exhibits inhibitory effects against non-small cell lung cancer (NSCLC) and alleviates the adverse effects associated with gefitinib_Metabolite study of culture medium supernatant

After screening the bacteria both in vivo and in vitro, it was found that a certain candidate strain could significantly inhibit non-small cell lung cancer when combined with the drug gefitinib and alleviate the side effects of gefitinib. Next, the mechanis...

2026-09-03 | MTBLS13843 | MetaboLights
MetabolomicsUntargeted metabolomics of Epicoccum layuense strain NJ-1 cell-free supernatant and Botryosphaeria dothidea responses to CFS treatment
This study investigated the metabolite composition of the cell-free supernatant (CFS) produced by Epicoccum layuense strain NJ-1 and the metabolic responses of Botryosphaeria dothidea to NJ-1 CFS treatment using untargeted metabolomics. The dataset includes untargeted metabolomic profiles of NJ-1 CF...
2026-09-05 | MTBLS15566 | MetaboLights
MetabolomicsLiquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model

Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
MetabolomicsDetection of metabolites in the supernatant of Lacticaseibacillus paracasei NCU-21
To investigate the important metabolites responsible for the antitumor activity of L. paracasei NCU-21, LC-MS/MS were employed for metabolomic analysis of the culture supernatant from L. paracasei NCU-21.
2026-04-02 | MTBLS14209 | MetaboLights
MetabolomicsAlterations in the metabolic footprint induced by Mayaro virus infection in cell culture
This study focuses metabolic footprinting of Vero cells infected by Mayaro virus. Nuclear magnetic resonance combined with multivariate analytical methods and tools of pattern recognition shows that metabolic changes can be attributed to the effect of Mayaro virus infection. Vero cells infected by M...
2021-10-28 | MTBLS639 | MetaboLights
MetabolomicsAntimicrobial Efficacy of Bifidobacterium longum FB1-4 Cell-Free Supernatant Against MRSA: Insights into Mechanisms and Food Matrix Application

The food safety landscape faces a significant challenge from methicillin-resistant Staphylococcus aureus (MRSA), a virulent and antibiotic-resistant foodborne pathogen. This study investigates the antimicrobial properties and mechanisms of cell-free supernatant (CFS) from Bifidobacterium longum F...

2026-02-26 | MTBLS13481 | MetaboLights
Sort   by:  
 Page size