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Proteomics7-Ketocholesterol overcomes drug resistance in Chronic Myeloid Leukemia cell lines beyond MDR1 mechanism_part2
Chronic myeloid leukemia (CML) is a myeloproliferative disease with a characteristic BCR-ABL tyrosine kinase (TK) fusion protein. Despite the clinical efficacy accomplished by TKIs therapies disease progression may affect patient response rate to these inhibitors due to a multitude of factors that c...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD003819 | Pride
Multidrug resistance Cell death and 7-ketocholesterol. Chronic myeloid leukemia Quantitative proteomics Human Oxysterols 
Proteomics7-Ketocholesterol overcomes drug resistance in Chronic Myeloid Leukemia cell lines beyond MDR1 mechanism_part3
Chronic myeloid leukemia (CML) is a myeloproliferative disease with a characteristic BCR-ABL tyrosine kinase (TK) fusion protein. Despite the clinical efficacy accomplished by TKIs therapies disease progression may affect patient response rate to these inhibitors due to a multitude of factors that c...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD003820 | Pride
Multidrug resistance Cell death and 7-ketocholesterol. Chronic myeloid leukemia Quantitative proteomics Human Oxysterols 
Proteomics7-Ketocholesterol overcomes drug resistance in Chronic Myeloid Leukemia cell lines beyond MDR1 mechanism_part1
Chronic myeloid leukemia (CML) is a myeloproliferative disease with a characteristic BCR-ABL tyrosine kinase (TK) fusion protein. Despite the clinical efficacy accomplished by TKIs therapies disease progression may affect patient response rate to these inhibitors due to a multitude of factors that c...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD003816 | Pride
Multidrug resistance Cell death and 7-ketocholesterol. Chronic myeloid leukemia Quantitative proteomics Human Oxysterols 
Unknown7-Ketocholesterol Promotes Oxiapoptophagy in Bone Marrow Mesenchymal Stem Cell from Patients with Acute Myeloid Leukemia.
Not available
S-EPMC6562391 | biostudies-literature
UnknownArgan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N.
Not available
S-EPMC5666899 | biostudies-literature
TranscriptomicsArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
RELEVANCE: Smith-Lemli-Opitz syndrome (SLOS) is a human disease caused by mutations in the gene coding for the enzyme DHCR7 (7-dehydrocholesterol (7DHC) reductase), which catalyzes the final step of cholesterol biosynthesis. Accumulated 7DHC in tissues and body fluids of SLOS patients gives rise t...
ORGANISM(S): Mus musculus 
2021-03-20 | E-MTAB-10055 | biostudies-arrayexpress
UnknownNAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells.
Not available
S-EPMC533993 | biostudies-literature
UnknownCell internalization of 7-ketocholesterol-containing nanoemulsion through LDL receptor reduces melanoma growth in vitro and in vivo: a preliminary report.
Not available
S-EPMC5865661 | biostudies-literature
UnknownCytoprotective effects of α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, oleic acid and α-tocopherol on 7-ketocholesterol - Induced oxiapoptophagy: Major roles of PI3-K / PDK-1 / Akt signaling pathway and glutathione peroxidase activity in cell rescue.
Not available
S-EPMC10877125 | biostudies-literature
UnknownExtra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL.
Not available
S-EPMC4363286 | biostudies-literature
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