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ProteomicsThermal proteome profiling reveals distinct target selectivity for differentially oxidized oxysterols
The dataset contains mass spectrometric raw data from Thermal Proteomic Profiling experiments aimed to identify the protein targets of three A- and B-ring oxidized sterols (cholestane-3beta,5alfa,6beta-triol (CT), 7keto-cholesterol (7-KC), 4beta-hydroxycholesterol (4beta-HC) ) and a side-chain oxidi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-16 | MSV000089661 | MassIVE
TranscriptomicsArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
RELEVANCE: Smith-Lemli-Opitz syndrome (SLOS) is a human disease caused by mutations in the gene coding for the enzyme DHCR7 (7-dehydrocholesterol (7DHC) reductase), which catalyzes the final step of cholesterol biosynthesis. Accumulated 7DHC in tissues and body fluids of SLOS patients gives rise t...
ORGANISM(S): Mus musculus 
2021-03-20 | E-MTAB-10055 | biostudies-arrayexpress
UnknownThe Role of Oxysterols in Human Cancer.
Not available
S-EPMC5474130 | biostudies-literature
UnknownCilia-Associated Oxysterols Activate Smoothened.
Not available
S-EPMC6503851 | biostudies-literature
UnknownEffects of Oxysterols on Immune Cells and Related Diseases.
Not available
S-EPMC9031443 | biostudies-literature
UnknownOxysterols Protect Epithelial Cells Against Pore-Forming Toxins.
Not available
S-EPMC8825411 | biostudies-literature
UnknownSide-Chain Immune Oxysterols Induce Neuroinflammation by Activating Microglia.
Not available
S-EPMC10607006 | biostudies-literature
ProteomicsOxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation.
Ozone (O3) is a prevalent air pollutant that causes lung inflammation following exposure. Previous studies demonstrate that O3 oxidizes lipids, such as cholesterol, in the airway to produce oxidized cholesterol products (oxysterols), such as secosterol-A (secoA), which form covalent linkages prefere...
ORGANISM(S): Homo sapiens (Human) 
2021-06-21 | PXD019824 | Pride
Human Lc-msms Airway epithelium Lung inflammasome Alkynylated secosterol Click Protein modification Ozone Secosterols 
UnknownOxysterols are allosteric activators of the oncoprotein Smoothened.
Not available
S-EPMC3262054 | biostudies-literature
UnknownImpact of Oxysterols on Cell Death, Proliferation, and Differentiation Induction: Current Status.
Not available
S-EPMC8468221 | biostudies-literature
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