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TranscriptomicsThe Kinase SGK1 in the Endoderm and Mesoderm Promotes Ectodermal Survival by Downregulating Components of the Death-Inducing Signaling Complex
A balance between cell survival and apoptosis is essential for animal development. Although proper development involves multiple interactions between germ layers, little is known about the intercellular and intertissue signaling pathways that promote cell survival in neighboring or distant germ laye...
ORGANISM(S): Xenopus laevis 
2011-02-21 | E-GEOD-26381 | biostudies-arrayexpress
TranscriptomicsHuman notochordal cell transcriptome in the developing intervertebral disc
The adult nucleus pulposus originates from the embryonic notochord, but loss of notochordal cells with skeletal maturity in humans is believed to initiate intervertebral disc degeneration. Thus, defining the phenotype of human embryonic/fetal notochordal cells is essential for understanding their ro...
ORGANISM(S): Homo sapiens 
2018-08-29 | E-MTAB-6868 | biostudies-arrayexpress
TranscriptomicsDownregulation of miR-760 Causes Human Intervertebral Disc Degeneration by Targeting the MyD88/Nuclear Factor-Kappa B Signaling Pathway
Dysregulation of microRNAs (miRNAs) plays a critical role in the development of intervertebral disc degeneration (IDD). In this study, we present evidence from in vitro and in vivo research to elucidate the mechanism underlying the role of miR-760 in IDD. miRNA microarray and quantitative reverse tr...
ORGANISM(S): Homo sapiens 
2022-03-17 | E-MTAB-11554 | biostudies-arrayexpress
TranscriptomicsThe long noncoding RNA expression profile of human intervertebral disc degeneration identified by microarray analysis
In addition to the well-known short noncoding RNAs as miRNAs, increasing evidence suggests that long noncoding RNAs (lncRNAs) act as key regulators in a wide aspect of biologic processes. Dysregulated expression of lncRNAs has been demonstrated being implicated in a variety of human diseases. Howeve...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-56081 | biostudies-arrayexpress
TranscriptomicsJAK/STAT coordinates cell proliferation during disc regeneration with Dilp8-mediated developmental delay in Drosophila melanogaster
Regeneration of fragmented Drosophila imaginal discs occurs in an epimorphic manner, involving local cell proliferation at the wound site. Following disc fragmentation, cells at the wound site activate a restoration program through wound healing, regenerative cell proliferation and repatterning of t...
ORGANISM(S): Drosophila melanogaster 
2015-04-10 | E-GEOD-54868 | biostudies-arrayexpress
TranscriptomicsHuman annulus disc cells grown in a 3D collagen sponge and exposed to TNF-a
The objective of this study was to determine how TNF-a, an important proinflammatory cytokine, affects gene expression in the human annulus. Cells were grown in a 3D collagen construct for 14 days with TNF-a. mRNA was isolated and subjected to microarray. Fold changes in gene expression were determ...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-41883 | biostudies-arrayexpress
TranscriptomicsExpression data from bovine nucleus pulposus interverteral disc cells
Assessment of the putative differential gene expression profiles in high osmolality-treated bovine nucleus pulposus intervertebral disc cells for a short (5 h) and a long (24 h) time period. Identification of novel genes up- or down-regulated as an early or a late response to hyperosmotic stress. A ...
ORGANISM(S): Bos taurus 
2015-06-19 | E-GEOD-59485 | biostudies-arrayexpress
TranscriptomicsTranscriptional signature of Drosophila wing disc regeneration
Research on the ability of certain organisms to reconstruct missing structures of their bodies is still in its infancy, despite numerous efforts performed in multiple species. Using expression profile analyses on different timepoints that cover wound healing and regeneration processes (0, 24 and 72 ...
ORGANISM(S): Drosophila melanogaster 
2010-10-22 | E-GEOD-17408 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus
Low back pain is a major cause of disability especially for people between 20 and 50 years of age. As a costly healthcare problem, it imposes a serious socio-economic burden. Current surgical therapies have considerable drawbacks and fail to replace the normal disc in facilitating spinal movements a...
ORGANISM(S): Homo sapiens 
2015-10-23 | E-GEOD-70362 | biostudies-arrayexpress
ProteomicsGiardia lamblia WBC 50803 ventral disc fractionation proteomics
Nosala C, Hagen KD, Hilton N, et al. Disc-associated proteins (DAPs) mediate the unusual hyperstability of Giardia's ventral disc. J Cell Sci. 2020; ejcs.227355.
ORGANISM(S): Giardia Lamblia Atcc 50803 (ncbitaxon:184922) 
2020-08-12 | MSV000085943 | MassIVE
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