Cell fate determination

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Unknown (1347)
Transcriptomics (1195)
Genomics (767)
Proteomics (71)
Other (23)
Methylation profiling (14)
Models (10)
Metabolomics (9)
Multiomics (3)

Organisms

Mus musculus (749)
Homo sapiens (469)
Arabidopsis thaliana (54)
Drosophila melanogaster (30)
Gallus gallus (22)
Danio rerio (22)
Caenorhabditis elegans (19)
Xenopus laevis (16)
Saccharomyces cerevisiae (11)
Rattus norvegicus (11)
Bos taurus (8)
Ciona intestinalis (6)
Oncorhynchus nerka (4)
Zea mays (4)
Zea mays subsp. mays (3)
Mycobacterium tuberculosis H37Rv (3)
Escherichia coli (3)
Sminthopsis crassicaudata (2)
Bacillus subtilis subsp. subtilis str. 168 (2)
Vitis vinifera (2)
Mycobacterium tuberculosis (2)
Cricetulus griseus (2)
Oryza sativa Japonica Group (2)
Cichorium intybus (2)
Methanosarcina acetivorans C2A (1)
Brassica oleracea (1)
Hypophthalmichthys nobilis (1)
Frankia alni ACN14a (1)
Caenorhabditis briggsae (1)
Pimephales promelas (1)

Organisms

Mus musculus (257)
Homo sapiens (144)
Danio rerio (11)
Arabidopsis thaliana (10)
Drosophila melanogaster (9)
Gallus gallus (8)
Caenorhabditis elegans (7)
Rattus norvegicus (3)
Bos taurus (3)
Cichorium intybus (1)
Hemicentrotus pulcherrimus (1)
Petromyzon marinus (1)
Marchantia polymorpha subsp. polymorpha (1)
Escherichia coli str. K-12 substr. MG1655 (1)
Caulobacter vibrioides NA1000 (1)
Lingula anatina (1)
Phaeodactylum tricornutum (1)
Oryctolagus cuniculus (1)
Apis mellifera (1)
Macaca mulatta (1)
Ovis aries (1)
Sus scrofa (1)
Ciona intestinalis (1)
Cryptosporidium parvum (1)
unidentified (1)
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Nicotiana tabacum (1)

Repository

biostudies-arrayexpress (969)
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geo (469)
pride (32)
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jPOST (7)
BioModels (5)
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PeptideAtlas (2)
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PanoramaPublic (1)

Tissue

Cell culture (11)
Stem cell (6)
Embryonic stem cell (3)
Primary cell (3)
Adipose tissue (2)
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Others (1)
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Mesenchymal cell (1)
Oocyte (1)
Seed (1)
Testis (1)
Xylem (1)

Disease

Disease free (3)
Normal (2)
MAS (1)
Locally advanced breast carcinoma (LABC; non-inflammatory) (1)
Autoimmune disorder (1)
Sarcoma (1)
Carcinoma (1)
Lung cancer (1)
Breast cancer (1)
Not Available (1)
Cardiovascular system disease (1)
Dengue disease (1)
Zika virus congenital syndrome (1)

Technology Type

Mass Spectrometry (32)
Shotgun proteomics (15)
Mass spectrometry (8)
Bottom-up proteomics (6)
Affinity purification coupled with mass spectrometry proteomics (4)
Chemiluminescence (3)
ELISA (3)
Chemical cross-linking coupled with mass spectrometry proteomics (3)
Data-dependent acquisition (2)
Data-independent acquisition (2)
Illumina HiSeq 2500, ILLUMINA (1)
Illumina HiSeq 2000, NextSeq 500, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 2000 (1)
Illumina HiSeq 2000, ILLUMINA (1)
Mass spectrometry assay (1)
All-ion fragmentation (1)
Metaproteomics (1)
SWATH MS (1)

Instrument Platform

Illumina NovaSeq 6000 (43)
NextSeq 500 (20)
Illumina HiSeq 4000 (19)
Illumina HiSeq 2000 (17)
Illumina HiSeq 2500 (15)
Fluidigm C1 (3)
Affymetrix Fluidics Station 400 (3)
Illumina Genome Analyzer IIx (2)
Illumina Genome Analyzer II (2)
Illumina NovaSeq X (2)
NextSeq 2000 (2)
10x 3’ single-cell mRNA v3 kit (10x Genomics) (1)
Qiagen RNEasy Mini ki (1)
BD FACSAriaIIu cell sorter (1)
BD FACS Aria II (1)
Poly-T oligo-attached magnetic beads (1)
Linux Bash Scripting (1)
NEBNext Ultra II Directional RNA Library Prep (1)
Qiagen RNeasy Mini Kit (1)
With L-glutamine supplemented with 10% fetal bovine serum (FBS) (Gibco) and 1% penicillin-streptomycin (10,000 units/mL penicillin and 10 mg/mL streptomycin) (Gibco). (1)
10X Genomics Chromium Controller Instrument, Thermocycler (PCR machine), Bioanalyzer 2200 (Agilent), Qubit Fluorometer (Thermo Fisher Scientific) (1)
Biological safety cabinet, Water bath (37°C), Centrifuge, 70 µm and 35 µm cell strainers, Countstar Fluorescence Cell Analyzer (1)
Surgical scalpel (1)
BD FACS ARIA III analyser (1)
Element AVITI (1)
Covaris (1)
10x Genomics Chromium (1)
Illumina Genome Analyzer Iix (1)
MoFlo XDP (Beckman Coulter) or a FACSAria II (Becton Dickinson) (1)
Fluidigm C1 autoprep system (1)

Publication Date

2015 (150)
2013 (137)
2014 (117)
2011 (106)
2016 (98)
2012 (95)
2025 (86)
2010 (85)
2023 (82)
2026 (72)
2022 (69)
2021 (68)
2024 (65)
2008 (64)
2009 (51)
2020 (49)
2018 (38)
2019 (35)
2007 (19)
2017 (18)
2006 (9)
2005 (5)
2004 (3)
2003 (1)

UNIPROT ID/AC

O14757 (2)
P25208 (1)
P10244 (1)
P30307 (1)
P30279 (1)
Q9ZWJ9 (1)
Q940D0 (1)
O82503 (1)
Q9FZ33 (1)
Q9SL42 (1)
Q570C0 (1)
Q08999 (1)
P42771 (1)
P11802 (1)
Q9C5U0 (1)
Q94JM3 (1)
P49677 (1)
P46527 (1)
Q01094 (1)
P24941 (1)
Q13535 (1)
P14635 (1)
P06493 (1)
P38936 (1)
P31947 (1)
P30304 (1)
Q12834 (1)
Q9Y6W6 (1)
Q05923 (1)
Q16690 (1)

CHEBI ID

CHEBI:37154 (2)
CHEBI:15971 (2)
CHEBI:32816 (2)
CHEBI:16347 (2)
CHEBI:17295 (2)
CHEBI:23530 (1)
CHEBI:22676 (1)
CHEBI:33699 (1)
CHEBI:94302 (1)
CHEBI:63550 (1)
CHEBI:27524 (1)
CHEBI:186165 (1)
CHEBI:16996 (1)
CHEBI:183136 (1)
CHEBI:88493 (1)
CHEBI:41378 (1)
CHEBI:1958 (1)
CHEBI:17282 (1)
CHEBI:170068 (1)
CHEBI:170157 (1)
CHEBI:170156 (1)
CHEBI:167375 (1)
CHEBI:167374 (1)
CHEBI:167373 (1)
CHEBI:167372 (1)
CHEBI:167371 (1)
CHEBI:167370 (1)
CHEBI:36493 (1)
CHEBI:167369 (1)
CHEBI:167368 (1)

Metabolite Name

Aldosterone (2)
9,10,18-trihydroxyoctadecanoic acid (1)
Ceramide phosphoethanolamine (d31:0) (1)
Ceramide phosphoethanolamine (t35:0) (1)
1-octadecyl-sn-glycero-3-phosphoinositol-3-phosphate (1)
Phosphatidylinositol (12:0) (1)
18-hydroxycorticosterone (1)
Thiamine(1+) diphosphate (1)
Unknown Sterol 10 (1)
Unknown Sterol 9 (1)
Unknown Sterol 8 (1)
Unknown Sterol 7 (1)
Unknown Sterol 6 (1)
Unknown Sterol 5 (1)
Unknown Sterol 4 (1)
Unknown Sterol 3 (1)
Unknown Sterol 2 (1)
Unknown Sterol 1 (1)
3,5,11-Eudesmatriene (1)
Selinan (1)
5-Methoxy-4,4,6-trimethyl-7-oxabicyclo[4.1.0]heptan-2-one (1)
8,9-Dehydrothymol methyl ether (1)
Tetrahydrocarvone (1)
2(3H)-Benzofuranone, hexahydro-3a,7a-dimethyl-, cis- (1)
Cis-p-Menthan-3-one (1)
3-Isopropyl-2-methylcyclopentanone (1)
Camphene hydrate (1)
Methyl 2-propylheptanoate (1)
2,3-Dehydro-1,8-cineole (1)
Beta-Pinene (1)

First Public Date

2025 (78)
2023 (70)
2026 (67)
2024 (64)
2022 (44)
2014 (43)
2020 (39)
2021 (30)
2019 (28)
2018 (26)
2015 (23)
2017 (11)
2016 (11)
2013 (8)

Modelling Approach

Ordinary differential equation model (5)

Lab affiliation

ANSES FOUGERES FRANCE (1)
BMG - University of Colorado - Anschutz Medical Campus (1)
CRUK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK (1)
Center for Cell Lineage and Development, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. (1)
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark (1)
Department of Chemistry, Boston College (1)
Department of Clinical Science, University of Bergen, Norway (1)
Department of Comparative Biosciences, University of Illinois at Urbana-Champaign (1)
Department of Humanbiology & BioImaging, Faculty of Biology, Ludwig-Maximilians-Universität München (1)
Department of Life Science, College of Life Science, National Taiwan University, Taipei, Taiwan (1)
Department of Microbial Proteomics, University of Greifswald, Greifswald, Germany (1)
Department of Molecular Physiology and Biological Physics University of Virginia School of Medicine Charlottesville, VA, USA 22908 (1)
Department of Molecular Sciences, Faculty of Science and Engineering, Macquarie University, North Ryde, NSW 2109, Australia (1)
Dr. Pietro Scaturro, Systems Arbovirology, Leibniz Institute of Virology, Hamburg, Germany (1)
ETH Zurich (1)
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland (1)
Institute For Systems Biology (1)
Laboratory of Molecular Biology (1)
Leibniz Institute on Aging - Fritz Lipmann Institute FLI (1)
MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China (1)
MRC Protein Phosphorylation & Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK (1)
Medizinisches Proteom-Center, Medical Faculty, Ruhr University Bochum, 44801 Bochum, Germany; 44801 Bochum, Germany (1)
PhD student, Linköping University (1)
Proteome Research AG Stühler Institute of Molecular Medicine I Heinrich Heine University Düsseldorf 40225 Düsseldorf (1)
Proteomic Facility, Institut Jacques Monod, UMR7592 (CNRS and Paris University) (1)
Proteomics Core Facility, Biozentrum, University of Basel, Spitalstrasse 41, CH-4056 Basel / Switzerland, Phone: +41 61 207 20 59, email: alex.schmidt@unibas.ch (1)
Proteomics program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark (1)
School of BioSciences, The University of Melbourne, Victoria, Australia (1)
Sun Yat-Sen University (1)
Sun Yat-sen University (1)

IsPrivate

False (5)

Classification

protozoa (1)
bacteria (1)

Study type

Transcription profiling by array (543)
RNA-seq of coding RNA (166)
ChIP-seq (96)
RNA-seq of coding RNA from single cells (48)
Other (17)
Cell line - High-throughput sequencing (8)
ChIP-chip by array (8)
Methylation profiling by array (8)
Methylation profiling by high throughput sequencing (8)
RNA-seq of non coding RNA (8)
Unknown experiment type (7)
ChIP-chip by tiling array (6)
RNA-seq of total RNA (6)
ATAC-seq (5)
Comparative genomic hybridization by array (4)
Transcription profiling by tiling array (3)
Transcription profiling by SAGE (2)
Baseline (2)
Human - Single-cell sequencing (2)
Cell line - One-color microarray (2)
Genotyping by array (2)
Transcription profiling by RT-PCR (2)
Bisulfite-seq (2)
RIP-seq (2)
DNA-seq (2)
Cell line - Single-cell sequencing (1)
Human - High-throughput sequencing (1)
High-throughput sequencing (1)
Human - One-color microarray (1)
Animal - High-throughput sequencing (1)

Release Date

2015 (182)
2014 (178)
2013 (176)
2022 (152)
2011 (140)
2021 (139)
2016 (137)
2012 (128)
2024 (115)
2023 (113)
2010 (112)
2025 (109)
2008 (93)
2020 (92)
2017 (89)
2019 (87)
2018 (83)
2009 (80)
2007 (40)
2026 (20)
2006 (17)
2004 (9)
2005 (7)
2003 (5)
2002 (3)
2001 (3)
1999 (2)
2000 (1)
1998 (1)
1997 (1)

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A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights

Disruption of Methionine Metabolism Drives Erythroid Cell Fate Reprogramming by Remodeling the H3K4me3 Landscape

Methionine cycle plays critical roles in cell fate determination by shaping epigenetic landscape, yet its function in human erythropoiesis remains undefined. Here, we show that disruption of methionine metabolism by compromising key enzyme adenosylhomocysteinase (AHCY) reshapes H3K4me3 landscape,...

2026-06-10 | MTBLS10469 | MetaboLights

Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics

Untargeted metabolomics is an established approach in toxicology for characterising endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its biotransformation products as part of the metabolomics analysis provides an opportunity to simultaneously gain deep insights int...

2023-07-03 | MTBLS2746 | MetaboLights

PRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis

PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...

2025-06-16 | MTBLS1639 | MetaboLights

Sexual cell fate reprogramming in the ovary by DMRT1

Transcription factors related to the insect sex determination gene Doublesex (DMRT proteins) control sex determination and/or sexual differentiation in diverse metazoans. They also are implicated in transitions between sex-determining mechanisms during vertebrate evolution. In mice Dmrt1 is required...

ORGANISM(S): Mus musculus

2015-02-27 | E-GEOD-64960 | biostudies-arrayexpress

Cell cycle dependence of neuroprogenitor fate determination regulated by Trrap-mediated histone acetylation

Epigenetic control of neural stem/progenitor cell fate is fundamental to achieve a fully brain architecture. Two intrinsic programs regulate neurogenesis, one by epigenetic-mediated gene transcription and another by cell cycle control. Whether and how these two are coordinated to determine temporall...

ORGANISM(S): Mus musculus

2014-05-01 | E-GEOD-43650 | biostudies-arrayexpress

Single-phage profiling illuminates viral individuality during cell fate determination

PRJNA1331651 | ENA

SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

Specification of primordial germ cells (PGCs) marks the beginning of the totipotent state. However, without a tractable experimental model, the mechanism of human PGC (hPGC) specification remains unclear. Here, we demonstrate specification of hPGC-like cells (hPGCLCs) from germline competent pluripo...

ORGANISM(S): Homo sapiens

2014-12-26 | E-GEOD-60138 | biostudies-arrayexpress

Single cell analysis of the impact of intermediate passaging on cell fate determination of mesendoderm progenitors

PRJNA1091694 | ENA

Matrix reverses immortalization-mediated stem cell fate determination

PRJNA625241 | ENA

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