Sort   by:  
 Page size 
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
ProteomicsActive repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis
Cell fate plasticity enables development, yet unlocked plasticity is a cancer hallmark. Regulating cell identity requires gene activation and repression. While master regulators induce lineage-specific genes to restrict plasticity, it remains unclear whether unwanted plasticity is actively suppresse...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-11 | PXD053043 | Pride
Cell fate plasticity Gene regulation Transcriptional repression Liver cancer Prox1 
MetabolomicsSMAD3 and HIF-1α Orchestrate Metabolic Transition to Aerobic Glycolysis as a Critical Prerequisite for Spontaneous Reprogramming of Spermatogonial Stem Cells

Spermatogonial stem cells (SSCs) possess the capacity for spontaneous reprogramming during in vitro culture, while the underlying mechanisms remain poorly understood, especially why addition of epidermal growth factor (EGF), leukemia inhibitory factor (LIF) remarkably enhanced transition efficien...

2025-07-08 | MTBLS12698 | MetaboLights
GenomicsHnrnpa21 regulates myogenic fate plasticity
Hnrnpa21 regulates myogenic fate plasticity
PRJNA639464 | ENA
ModelsCarbo2013 - Cytokine driven CD4+ T Cell differentiation and phenotype plasticity
Carbo2013 - Cytokine driven CD4+ T Cell differentiation and phenotype plasticity CD4+ T cells can differentiate into different phenotypes depending on the cytokine milieu. Here a computational and mathematical model with sixty ordinary differential equations representing a CD4+ T ...
2024-09-02 | BIOMD0000000451 | BioModels
UnknownLifting regenerative barriers promotes epithelial cell fate plasticity supporting lineage conversion.
Not available
S-EPMC12722390 | biostudies-literature
GenomicsFate plasticity of interneuron specification
Fate plasticity of interneuron specification
PRJNA1167741 | ENA
GenomicsIRAK4 constrains cellular plasticity during chemically-induced cell fate reprogramming into multiple lineages
IRAK4 constrains cellular plasticity during chemically-induced cell fate reprogramming into multiple lineages
PRJNA1452973 | ENA
UnknownReconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors.
Not available
S-EPMC7469703 | biostudies-literature
GenomicsActive repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis [PROX1 OE Hep3B RNA-seq]
Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis [PROX1 OE Hep3B RNA-seq]
PRJNA1199994 | ENA
Sort   by:  
 Page size