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TranscriptomicsTranscription profiling of mouse hepatoblasts
The homeobox transcription factor Prox1 is expressed in embryonic hepatoblasts and remains expressed in adult hepatocytes. Prox1-null mice show severe deficiencies of liver development, but the underlying mechanisms are unknown. We studied the effects of Prox1 on the transcriptional profile of embry...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7867 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile changes by Prox1 expression in thyroid cancer cells
Human thyroid cancer cell line BCPAP was engineered for doxycyclin-mediated inducible expressoin of Prox1 and next generation sequcing was performed to study the transcriptional regulation by Prox1 BCPAP cells were infected with rTTA2 lentivirus. The resulting cell populations were then stably trans...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-75059 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of PROX1 overexpression and knockdown in glioblastoma cell lines
Glioblastoma represents the most common and aggressive primary brain tumor type in adults. Stem cell regulatory pathways have been shown to be activated in gliomas supporting self-renewal, tumor maintenance and survival under stress. Glioblastoma stem-like phenotype, cell motility and tumor cell het...
ORGANISM(S): Homo sapiens 
2018-12-29 | E-MTAB-6991 | biostudies-arrayexpress
ProteomicsActive repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis
Cell fate plasticity enables development, yet unlocked plasticity is a cancer hallmark. Regulating cell identity requires gene activation and repression. While master regulators induce lineage-specific genes to restrict plasticity, it remains unclear whether unwanted plasticity is actively suppresse...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-11 | PXD053043 | Pride
Cell fate plasticity Gene regulation Transcriptional repression Liver cancer Prox1 
TranscriptomicsRNAi knock down using siRNAs targeting PROX1 or GFP in human colon carcinoma cells
siRNA transfection using either two different siRNAs targeting PROX1 or GFP
ORGANISM(S): Homo sapiens 
2008-09-03 | E-MEXP-1422 | biostudies-arrayexpress
TranscriptomicsProx1 haploinsufficiency sensitizes the pancreas to KrasG12D-induced transformation
Oncogenic mutations in Kras initiate neoplastic transformation in the pancreas through a process that hijacks the activity of developmental regulators and induces an inflammatory microenvironment. We report that the homeodomain transcription factor Prox1 is a novel component of a progenitor signatu...
ORGANISM(S): Homo sapiens 
2016-02-11 | E-GEOD-58547 | biostudies-arrayexpress
TranscriptomicsProx1 downregulation is a prerequisite for the maturation and expansion of postnatal murine beta cells
Alterations in the expression of key transcription factors can be harmful for pancreatic beta cell homeostasis and could lead to diabetes. This study uncovered that Prox1 overexpression obstructs beta cell maturation and results in severe hyperglycemia. The function of β-cells is key for glucose ho...
ORGANISM(S): Mus musculus 
2016-02-11 | E-GEOD-68133 | biostudies-arrayexpress
ProteomicsFasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism
Accumulation of excess nutrients hampers proper liver function and is linked to non-alcoholic fatty liver disease (NAFLD) in obesity. However, the signals responsible for an impaired adaptation of hepatocytes to obesogenic dietary cues remain still largely unknown. Post-translational modification b...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD041329 | Pride
Prox1 Sumoylation Cholesterol Liver Bile acids 
TranscriptomicsProx1 (Prosper-related homeobox 1) transcription factor depletion effect on CGTH-W-1 cells.
Analysis of CGTH-W-1 follicular thyroid carcinoma cells transcriptome following 48 hrs siRNA-mediated depletion of PROX1. PROX1 is a homeobox transcription factor. PROX1 depletion decreases migratory ability, motility and invasivness and induces profound cytoskeleton changes of CGTH-W-1 cells. ...
ORGANISM(S): Homo sapiens 
2016-07-31 | E-GEOD-80135 | biostudies-arrayexpress
GenomicsProx1 in VIP interneurons
VIP subtype-specific role for Prox1 in circuit integration
PRJEB37790 | ENA
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