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This study performed untargeted LC–MS metabolomic profiling of fresh leaf tissues from seven representative Ophiorrhiza sensu lato taxa: O. subpunicea, O. cantonensis, O. pumila, O. shiqianensis, O. humilis, O. huanjiangensis, and O. hispidula. Metabolites were extracted using a methanol–acetonitril...
2026-07-21 | MTBLS15110 | MetaboLights

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights

Amidst the mismatch between domestic feed supply and demand in China, along with the competition for food between humans and animals, optimizing feed efficiency has become crucial for industry growth. Nevertheless, the biological processes driving variations in feed efficiency remain unexplored. ...

2026-03-10 | MTBLS14013 | MetaboLights

Amidst the mismatch between domestic feed supply and demand in China, along with the competition for food between humans and animals, optimizing feed efficiency has become crucial for industry growth. Nevertheless, the biological processes driving variations in feed efficiency remain unexplored. ...

2026-03-10 | MTBLS14017 | MetaboLights

Amidst the mismatch between domestic feed supply and demand in China, along with the competition for food between humans and animals, optimizing feed efficiency has become crucial for industry growth. Nevertheless, the biological processes driving variations in feed efficiency remain unexplored. ...

2026-03-10 | MTBLS14009 | MetaboLights

The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate aspects of B cell proliferation and differentiation into germinal center (GC) and PC states...

2026-04-13 | MTBLS13880 | MetaboLights
Chickarmane2008 - Stem cell lineage determination In this work, a dynamical model of lineage determination based upon a minimal circuit, as discussed in PMID: 17215298 , which contains the Oct4/Sox2/Nanog core as well its interaction with a few other key genes ...
2024-09-02 | BIOMD0000000209 | BioModels

Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigated how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors...

2024-04-30 | MTBLS9914 | MetaboLights
Chickarmane2008 - Stem cell lineage - NANOG GATA-6 switch In this work, a dynamical model of lineage determination based upon a minimal circuit, as discussed in PMID: 17215298 , which contains the Oct4/Sox2/Nanog core as well its interaction with a few other ke...
2024-09-02 | BIOMD0000000210 | BioModels
This SuperSeries is composed of the following subset Series: GSE40684: Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [ChIP-Seq] GSE40685: Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [Expression] Refer to in...
ORGANISM(S): Mus musculus 
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