Overcoming resistance to chemotherapies remains a major unmet need for cancers such as triple negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for drug development are urgently needed to overcome TNBC therapy resistance. Recently, an important role of fatty acid β-...

This study compared three cotton-stalk processing strategies—grinding (FS), steam explosion (PH), and microbial fermentation (FJ)—and evaluated whether the barrier-preserving phenotype observed with fermented cotton stalks is associated with coordinated changes in the microbiota–metabolite milieu...

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...