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MetabolomicsA metabolic dependency of EBV can be targeted to hinder B cell transformation

Following infection of B cells, Epstein Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates NAD de novo bios...

2024-04-29 | MTBLS2243 | MetaboLights
MetabolomicsDynamic single-cell metabolomics reveals cell-cell interaction between tumor cells and macrophages

Single-cell metabolomics reveals cell heterogeneity and elucidates intracellular molecular mechanisms. However, general concentration measurement of metabolites can only provide a static delineation of metabolomics, lacking the metabolic activity information of biological pathways. Herein, we dev...

2025-04-14 | MTBLS11091 | MetaboLights
MetabolomicsModerate salinity restricts the transformation depth of norfloxacin by halotolerant Chlorella sp. AMC-2: Physiological adaptation and metabolic reprogramming
Despite increasing application of microalgae for antibiotic-contaminated aquaculture wastewater treatment, how salinity regulates antibiotic transformation depth and cellular adaptation remains unclear. This study combined salinity-gradient cultivation, process partitioning, transformation-product p...
2026-10-01 | MTBLS15888 | MetaboLights
MetabolomicsMicrobial transformation of dietary xenobiotics shapes gut microbiome composition

Diet is a major determinant of gut microbiome composition, and variation in diet-microbiome interactions may contribute to variation in their health consequences. Understanding individual differences requires mechanistic understanding of dietary xenobiotics-microbiome interactions. Here, we map i...

2024-08-06 | MTBLS9221 | MetaboLights
MetabolomicsSingle-cell thiol profiling enabled by live-cell labeling reveals metabolic heterogeneity in ferroptosis

Raw data of both bulk and single-cell metabolomics. It includes all MS, LC-MS and LC-MS/MS raw data associated with the article 'Single-cell thiol profiling enabled by live-cell labeling reveals metabolic heterogeneity in ferroptosis'.

2026-02-14 | MTBLS13900 | MetaboLights
MetabolomicsNormalization strategies for lipidome data in cell line panels & Distinct lipidomic profiles in breast cancer cell lines relate to proliferation and EMT phenotypes

Sample collection can significantly affect measurements of relative lipid concentrations in cell line panels, hiding intrinsic biological properties of interest between cell lines. Most quality control steps in lipidomic data analysis focus on controlling technical variation. Correcting for the t...

2025-08-07 | MTBLS9493 | MetaboLights
MetabolomicsMetabolomics reveals increased toxicity in earthworms (Eisenia fetida) of the transformation product methyl-triclosan
The effects of the antimicrobial triclosan (TCS) and its transformation product methyl-triclosan (MTCS) on the earthworm Eisenia fetida were investigated using GC-MS metabolomics. TCS is ubiquitous in sewage sludge, but a large proportion is transformed into MTCS during wastewater treatment and in s...
2018-09-17 | MTBLS532 | MetaboLights
MetabolomicsSingle-cell lipidomic analysis of the Epithelial-Mesenchymal Transition (EMT) using MALDI-MSI

EMT is a metastasis-promoting process whose heterogeneity has been extensively studied at a gene expression level. EMT also involves reprogramming of lipid metabolism, however there has been little focus on heterogeneity on the lipid level. Here, we use MALDI-MSI to determine the levels of variou...

2026-04-15 | MTBLS12650 | MetaboLights
MetabolomicsSnail reprograms glucose metabolism by repressing PFKP allowing cancer cell survival under metabolic stress
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial-mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...
2017-11-07 | MTBLS387 | MetaboLights
TranscriptomicsIdentification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach.
Employing MCT-1 oncogene mediated transformation of immortalized breast epithelial MCF10A cells; we characterized the largely reciprocal association of these two RBPs with target mRNAs and their influence on protein expression vis-à-vis cellular transformation. Using a ribonomics approach, we ident...
ORGANISM(S): Homo sapiens 
2008-07-29 | E-GEOD-12215 | biostudies-arrayexpress
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