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MetabolomicsSnail reprograms glucose metabolism by repressing PFKP allowing cancer cell survival under metabolic stress
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial-mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...
2017-11-07 | MTBLS387 | MetaboLights
MetabolomicsSystem Xc- exacerbates metabolic stress under glucose depletion in oral squamous cell carcinoma

OBJECTIVE: Emerging evidence suggests that glucose depletion (GD)-induced cell death depends on system Xc-, a glutamate/cystine antiporter extensively studied in ferroptosis. However, the underlying mechanism remains debated. Our study confirmed the correlation between system Xc...

2024-01-16 | MTBLS5358 | MetaboLights
ProteomicsAlgal Protein Kinase, Triacylglycerol Accumulation Regulator1, Modulates Cell Viability and Gametogenesis in Carbon/Nitrogen Imbalanced Conditions
Nutrient-deprived microalgae accumulate triacylglycerol (TAG) in lipid droplets. A Dual-specificity tyrosine phosphorylation-regulated kinase, TAG-accumulation-regulator-1 (TAR1) has been shown to be required for acetate-dependent TAG accumulation and degradation of chlorophyll and photosynthesis-re...
ORGANISM(S): Chlamydomonas 
2019-07-22 | PXD012391 | JPOST Repository
MetabolomicsWhat CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines

Background: Cell line specific, genome-scale metabolic models enable rigorous and systematic in silico investigation of cellular metabolism. Such models have recently become available for Chinese hamster ovary (CHO) too. However, a key ingredient, namely an experimentally validat...

2020-07-13 | MTBLS1210 | MetaboLights
ProteomicsOGT controls mammalian cell viability by regulating the proteasome/mTOR/mitochondrial axis
TMT-based proteomic and phosphoproteomic analysis of mouse embryonic stem cells upon deletion of Ogt.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-11-16 | MSV000088393 | MassIVE
MetabolomicsHERPES SIMPLEX VIRUS TYPE 1 IMPAIRS DENDRITIC CELL FUNCTION BY REMODELLING NEUTRAL LIPID METABOLISM AND INDUCING LIPID DROPLET ACCUMULATION
Herpes simplex virus type 1 (HSV-1) infects dendritic cells (DCs), professional antigen-presenting cells that initiate and regulate host antiviral responses. HSV-1 infects DCs limiting their maturation, migration to draining lymph nodes and T cell activation capacity, ultimately promotes their apopt...
2025-04-03 | MTBLS5163 | MetaboLights
TranscriptomicsSensing prokaryotic mRNA signifies microbial viability and promotes immunity
MyD88-independent signal transduction associated with Toll-like receptors (TLRs) 3 and TLR4 is mediated through the adapter protein TRIF (TIR-domain-containing adapter-inducing interferon-beta). It has been proposed that TLR signalling is important for the transcription of crucial inflammasome compo...
ORGANISM(S): Mus musculus 
2011-05-22 | E-GEOD-27960 | biostudies-arrayexpress
GenomicsThe effect of berberine upon HepG2 cell viability
The effect of berberine upon HepG2 cell viability
PRJNA691210 | ENA
TranscriptomicsSeminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts.
Exposure of eEC and eSF to SP in vitro increases expression of genes and secreted proteins associated with cellular migration, proliferation, viability and inhibition of cell death. This is a cross sectional study involving control samples versus treatment. SP (pooled from twenty donors) was first t...
ORGANISM(S): Homo sapiens 
2014-05-07 | E-GEOD-57356 | biostudies-arrayexpress
MetabolomicsThe effects of oligomycin administration and glutamine deprivation on metabolic profile of MCF7 breast cancer cell line measured using [1,2-13C2]-D-glucose and [U-13C5]-L-glutamine as tracers
This study aims to establish a comprehensive, genome-scale metabolic model (GSMM) combining different omics data of different regulatory levels of breast cancer cells in order to elucidate the way that these regulatory levels affect or determine each other. Together with transcriptomics, proteomics ...
2021-01-18 | MTBLS183 | MetaboLights
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