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MetabolomicsExploring the effect of estrogen on Candida albicans hyphal cell wall glycans and ergosterol synthesis
Increased levels of 17-β estradiol (E2) due to pregnancy in young women or to hormonal replacement therapy in postmenopausal women have long been associated with an increased risk of yeast infections. Nevertheless, the effect underlying the role of E2 in Candida albicans infections is not wel...
2025-09-11 | MTBLS5821 | MetaboLights
MetabolomicsNitrate Reductase NarGHJI Modulates Vancomycin Susceptibility by Coordinating Cell Wall Remodeling and Agmatine Metabolism in Staphylococcus aureus
Staphylococcus aureus is a ubiquitous pathogen responsible for a wide range of severe infections. Our previous work established that the nitrate reductase NarGHJI modulates bacterial pathogenicity through regulation of the agr system, yet its role in antibiotic resistance remains poorly understood. ...
2026-07-07 | MTBLS14968 | MetaboLights
TranscriptomicsTranscriptional changes associated to resistance to the cell wall active bacteriocin Lcn972
Lcn972 is a non-modified bacteriocin that targets exclusively Lactococcus sp. Addition of Lcn972 inhibits cell wall biosynthesis at the septum by binding to the cell wall precursor lipid II. Resistance to Lcn972 develops upon selection with subinhibitory concentrations. The transcriptome of the high...
ORGANISM(S): Lactococcus lactis subsp. lactis 
2012-12-06 | E-GEOD-38349 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of secondary cell wall development in Medicago truncatula
Global transcriptional profiling has been successfully used to identify genes and regulatory pathways in secondary cell wall thickening. A systematic microarray assay of secondary cell wall development along stem maturation in Medicago truncatula was conducted to identify genes and pathways that are...
ORGANISM(S): Medicago truncatula 
2016-06-28 | E-MTAB-3909 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis stem, leaf and hypocotyl tissue undergoing varying amounts of secondary cell wall synthesis
The aim of this experiment was to understand secondary cell wall formation as it is a major constituent of wood and plant fibres. To identify potential novel genes involved in this process, data has been generated from Arabidopsis stem, leaf and hypocotyl tissue undergoing varying amounts of seconda...
ORGANISM(S): Arabidopsis thaliana 
2006-01-01 | E-MEXP-265 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of Arabidopsis seedlings treated with the cellulose biosynthesis inhibitor isoxaben
We are interested in understanding how plants respond to cell wall stress. The stress is created through inhibition of cellulose biosynthesis. Isoxaben is a drug that inhibits cellulose biosynthesis in a dose dependent manner. We used a concentration of 600 nM isoxaben which should inhibit appr. 80%...
ORGANISM(S): Arabidopsis thaliana 
2008-01-08 | E-MEXP-711 | biostudies-arrayexpress
TranscriptomicsInhibitors that block initiation of wall teichoic acid biosynthesis sensitize methicillin-resistant Staphylococcus aureus to beta-lactams
Methicillin resistance in Staphylococcus aureus depends on the production of mecA, which encodes penicillin-binding protein 2A (PBP2A), an acquired peptidoglycan transpeptidase with reduced susceptibility to beta-lactam antibiotics. Here, we show that preventing the expression of wall teichoic acids...
ORGANISM(S): Staphylococcus aureus 
2010-10-19 | E-GEOD-24439 | biostudies-arrayexpress
ProteomicsCell wall proteome of Tuwongella immobilis
Bacteria of the Planctomycetes phylum have many unique cellular features, such as extensive membrane invaginations and the ability to import macromolecules. These features raise intriguing questions about the composition of their cell envelopes. In this study, we have used microscopy, phylogenomics ...
ORGANISM(S): Tuwongella immobilis Bacteria 
2020-08-10 | PXD019121 | Pride
Planctomycetes Tuwongella immobilis Cell wall Lc-ms/ms 
ProteomicsThe Cell Wall Proteome of Craterostigma plantagineum Cell Cultures Habituated to Dichlobenil and Isoxaben
The remarkable desiccation tolerance of the vegetative tissues in the resurrection species Craterostigma plantagineum (Hochst.) is favored by its unique cell wall folding mechanism that allows the ordered and reversible shrinking of the cells without damaging neither the cell wall nor the underlying...
ORGANISM(S): Craterostigma plantagineum 
2021-11-03 | PXD026733 | Pride
Craterostigma plantagineum  dichlobenil  isoxaben  habituation  cell wall  qpcr  proteomics. 
TranscriptomicsTranscription profiling of Staphylococcus aureus following inhibition of early-stage cell-wall biosynthesis
Data is also available from http://bugs.sgul.ac.uk/E-BUGS-71
ORGANISM(S): Staphylococcus aureus 
2009-01-27 | E-BUGS-71 | biostudies-arrayexpress
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