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Most bacteria possess a peptidoglycan cell wall, which is continuously remodeled during cell growth and divi¬sion. The peptidoglycan (PG) fragments generated in this process are typically imported into the cell and recycles through the PG biosynthesis pathway. While the underlying pathways have been...
ORGANISM(S): Caulobacter crescentus (strain NA1000 / CB15N) 
2026-03-11 | PXD069004 | Pride
A defect in cell wall recycling confers antibiotic resistance and sensitivity in Staphylococcus aureus.
WalKR is a two-component system that is essential for viability in Gram-positive bacteria that regulates the all-important autolysins. Here we show a T101M mutation in walR confers a defect in autolysis, a thickened cell wall and decreased sensitivity to antibiotics that target the lipid II cycle, a...
ORGANISM(S): Staphylococcus aureus 
2022-08-25 | GSE211745 | GEO
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