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MetabolomicsNanoinducers-mediated Mitochondria-Selective Degradation Enhance T Cell Immunotherapy Against Multiple Cancers

Cancer immunotherapy utilizing cytotoxic T lymphocytes (CTLs) has demonstrated significant promise in clinical applications, but cancer immunosuppressive mechanisms hamper further progress in T cell immunotherapy. Here we show a correlation between cancer cell mitochondria content and their resis...

2025-03-13 | MTBLS12284 | MetaboLights
MetabolomicsCirculating cell populations as response predictors and targets to improve immunotherapy in metastatic lung cancer

The effectiveness of immunotherapy varies among patients with advanced non-small cell lung cancer (NSCLC). Here we investigated the baseline immune status in stage IV NSCLC patients treated with anti-PD-1 plus chemotherapy to understand the immune mechanisms and unveil systemic markers associated...

2025-10-16 | MTBLS13150 | MetaboLights
MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
MetabolomicsABCA1-mediated cholesterol transfer in gastric cancer immunity
This study investigates how ABCA1-mediated cholesterol transfer from gastric cancer cells affects the antitumor function of human Vgamma9Vdelta2 T cells. It examines the relationship between cholesterol accumulation, NF-kappaB signaling, and T-cell effector function, and evaluates whether targeting ...
2026-10-21 | MTBLS16098 | MetaboLights
TranscriptomicsIL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
IL-2 and IL-21 are closely related cytokines that might have arisen by gene duplication. Both cytokines promote the function of effector CD8+ T cells, but their distinct effects on antigen-driven differentiation of naïve CD8+ T cells into effector CD8+ T cells are not clearly understood. We found t...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10403 | biostudies-arrayexpress
ProteomicsForced Intracellular degradation of Xenoantigens as a modality for cell-based cancer immunotherapy
Given recent leverage of mesenchymal stromal cells (MSCs) as a potent vaccination platform, we investigated whether forced degradation of an expressed experimental antigen fused to small degron sequences could prime potent antitumoral responses. Retrovirally gene-engineered MSCs were evaluated for t...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-17 | PXD059791 | Pride
Xenoantigens Mesenchymal stromal cells Immunopeptidomics Cell-based cancer immunotherapy 
ProteomicsThe Immunopeptidomic Landscape of Ependymomas provide actionable antigens for T cell-based immunotherapy
Ependymoma (EPN) are primary tumors of the nervous system. Due to their growth pattern, most ependymoma can be managed with neurosurgical resection alone. A substantial proportion of these tumors recurs or display infiltrative growth pattern, however. Therapeutic options after neurosurgical resectio...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD052448 | Pride
Peptide vaccine Hla ligands Mass spectrometry Cancer vaccination Neuroepithelial tumor Immunotherapy 
GenomicsA Cryogel-Based Dendritic Cell Vaccine for Post-Surgical Breast Cancer Immunotherapy
A Cryogel-Based Dendritic Cell Vaccine for Post-Surgical Breast Cancer Immunotherapy
PRJNA1222443 | ENA
ProteomicsMulti-omics analysis reveals the sensitivity of immunotherapy for unresectable non-small cell lung cancer
Peripheral blood plasma was collected from unresectable stage III and IV non-small cell lung cancer patients who were negative for driver mutations before receiving immunotherapy. Then we classified samples according to the follow-up results after two courses of immunotherapy and non-targeted metabo...
ORGANISM(S): Homo Sapiens 
2024-12-18 | PXD058967 |
ProteomicsIdentification of proteins deregulated by platinum-based chemotherapy as novel biomarkers and therapeutic targets in non-small cell lung cancer
Platinum-based chemotherapy remains the cornerstone of treatment for most people with non-small cell lung cancer (NSCLC), either as adjuvant therapy in combination with a second cytotoxic agent or in combination with immunotherapy. Resistance to therapy, either in the form of primary refractory dise...
ORGANISM(S): Homo Sapiens 
PXD024209 | panorama
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